RBL1 Antibody
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中文名稱：RBL1兔多克隆抗體
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貨號：CSB-PA040183
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：107 kDa retinoblastoma-associated protein antibody; Cellular protein 107 antibody; Cellular protein p107 antibody; CP107 antibody; MGC40006 antibody; p107 antibody; PRB1 antibody; RBL1 antibody; RBL1_HUMAN antibody; Retinoblastoma like protein 1 antibody; retinoblastoma-like 1 (p107) antibody; Retinoblastoma-like protein 1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from Human p107 around the non-phosphorylation site of T369.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：IF, ELISA
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推薦稀釋比：
Application Recommended Dilution IF 1:200-1:1000 ELISA 1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor.
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基因功能參考文獻：
- Study found that the methylation of global DNA decreased gradually after irradiation, and the methylation of the promoter of RBL1 gene may play an important role in the induction of radioresistance for three dimensional cultured carcinoma cells. PMID: 27779109
- These findings in human skeletal muscle suggest that attenuated transcriptional repression through p107 may be a novel mechanism by which exercise stimulates mitochondrial biogenesis following exercise. PMID: 28270591
- The authors found that phosphorylation of residues S650 and S975 in p107 weakens the E2F4 transactivation domain binding. PMID: 27567532
- UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins PMID: 28289097
- Sequence analysis of the RB1 gene detected a novel mutation in bilateral retinoblastoma. PMID: 22729126
- MAGE-A11 is a proto-oncogene whose increased expression in prostate cancer reverses retinoblastoma-related protein p107 from a transcriptional repressor to a transcriptional activator of the androgen receptor and E2F1. PMID: 23853093
- Single nucleotide polymorphism in the ultraconserved elements of RBL1 gene is associated with recurrence in colorectal adenocarcinoma. PMID: 22673945
- Concomitant germline large cytogenetic 13q deletion and somatic mutations in the RB1 gene in unilateral retinoblastoma. PMID: 22303805
- may have a role in the mechanisms of proliferation and differentiation during human placental development PMID: 11642725
- regulation of expression of p130, p107 and E2F-4 in human cells PMID: 12006580
- suggests that the p107 N-terminus provides an interaction domain for transcription factors involved in cell cycle control PMID: 12439743
- report shows hypophosphorylation of the retinoblastoma family proteins induced by H2O2 was because of the activity of protein phosphatase 2A PMID: 12621062
- p107 plays a constitutive role in the progression of papillary carcinoma of the thyroid and that decreased p107 expression may contribute to the transformation from follicular adenoma to follicular carcinoma and anaplastic transformation. PMID: 14666683
- Induction of p130 and p107 play an important role in the inhibition of growth of C33A cells by MIS. PMID: 14671316
- the PP2A catalytic subunit (PP2A/C) specifically interacts with both p130 and p107 in quiescent cells as well as cells progressing throughout the cell cycle PMID: 15467457
- Data suggest that p107, in addition to its interaction with E2F, inhibits cell proliferation through the control of Skp2 expression and the resulting stabilization of p27. PMID: 15631990
- p107 is a trancriptional regulator of the cell cycle genes. PMID: 16135806
- These results demonstrate a mechanistic role for p130 and compensatory roles for p107 and RB in the long-term senescence-like growth arrest response of breast cancer cells to DNA damage. PMID: 16537896
- The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction. PMID: 17563750
- Differentiating human adipose-derived human stem cells (hASC), do not undergo clonal expansion and p130 expression gradually diminishes across differentiation. However, p107 expression is transiently increased during hASC differentiation. PMID: 18086563
- P107 is needed for initiation of accelerated cellular senescence in the absence of Rb and introduces the concept that p130 may be required to prevent the onset of terminal growth arrest in unstimulated prostate cancer cells lacking a functional Rb allele. PMID: 18418057
- These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the homotypic vacuolar protein sorting complex. PMID: 18799622
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亞細胞定位：Nucleus.
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蛋白家族：Retinoblastoma protein (RB) family
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數據庫鏈接：
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