RAMP1 Antibody

說明書

中文名稱：

RAMP1兔多克隆抗體
貨號：

CSB-PA019304GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O60894
基因名：

RAMP1
別名：

RAMP1; Receptor activity-modifying protein 1; Calcitonin-receptor-like receptor activity-modifying protein 1; CRLR activity-modifying protein 1
宿主：

Rabbit
反應種屬：

Human
免疫原：

Human RAMP1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.
基因功能參考文獻：
1. T-A-T RAMP1 gene haplotype might have utility as a genetic marker for Essential Hypertension and that the RAMP1 gene may be associated with increased susceptibility to Essential Hypertension in a Japanese population. PMID: 28181496
2. Evidence that DNA methylation at RAMP1 gene promoter plays a role in migraine was described. PMID: 26501962
3. RAMP1 rs7590387 has a role in the transformation of episodic migraine into medication overuse headache. PMID: 25881990
4. A novel functional role for RAMP1 in regulation of CaSR signalling in addition to its known role in receptor trafficking, is reported. PMID: 24454825
5. multiple NKX3.1 binding sites were found in the RAMP1 locus in human prostate cancer cells and in the normal mouse prostate. PMID: 23867798
6. RAMP1 overexpression enhances the promoting effect that exogenous CGRP has on osteogenic differentiation PMID: 22949393
7. No significant association of the tested SNPs of the RAMP1 gene were found with migraine susceptibility. PMID: 23237777
8. CLR and RAMP1 co-localize in the enteric nervous system of human stomach, ileum, and colon, and are in close proximity to their ligands CGRP and IMD PMID: 22484227
9. The present finding demonstrated that RAMP1 immunoreactivity was localized in many neurons and phenopalatine ganglion. PMID: 22208649
10. lower expression in bronchial biopsies from subjects with asthma PMID: 20933260
11. The T-A-C haplotype is a genetic marker for cerebral infarction, and RAMP1 is associated with increased susceptibility to cerebral infarction. PMID: 19710695
12. These data for the first time pinpoint a specific RAMP1 residue important for both antagonist and agonist potency and are consistent with the N-terminal domain of RAMP1 forming the binding pocket interface with calcitonin receptor-like receptor. PMID: 20188075
13. RAMP1 overexpression attenuates Ang-II-induced hypertension and induces a protective change in cardiovascular autonomic regulation PMID: 20100989
14. Co-expression of RAMP1 and CRLR reconstituted a CGRP receptor that was able to activate the pheromone-signaling pathway with pharmacological properties similar to those observed previously in mammalian cells. PMID: 11733510
15. Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists. PMID: 11847213
16. The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function PMID: 12574158
17. identification of domains responsible for agonist binding specificity PMID: 12684503
18. TNF-alpha induced time- and dose-dependent decreases in the expression of RAMP1 mRNA in cultured human coronary artery smooth muscle cells, thereby diminishing AM-evoked cAMP production PMID: 15245870
19. calcitonin receptor-like receptor heterodimer with RAMP1 yields a calcitonin gene-related peptide receptor PMID: 15613468
20. RAMP1 interacts with tubulin. PMID: 17493758
21. Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor and RAMP1. PMID: 17785463
22. We did not observe any difference in mRNA for CL-R and RAMPs in arteries from patients with hemorrhagic stroke, arteriosclerosis and acute myocardial infarction when compared to patients without these diagnoses PMID: 18198792
23. RAMP1 may be strongly considered as a candidate gene for migraine. PMID: 18240900
24. Identification of RAMP1 residues important for calcitonin gene-related peptide are reported. PMID: 18593822
25. the crystal structure of the extracellular domain of human RAMP1 at 2.4 A resolution was determined. PMID: 18725456
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

RAMP family
組織特異性：

Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.
數據庫鏈接：

HGNC: 9843

OMIM: 605153

KEGG: hsa:10267

STRING: 9606.ENSP00000254661

UniGene: Hs.471783

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