RAD54B Antibody

中文名稱：

RAD54B兔多克隆抗體
貨號：

CSB-PA896748LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA896748LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA896748LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA896748LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RAD54B Polyclonal antibody
Uniprot No.：

Q9Y620
基因名：

RAD54B
別名：

RAD54B antibody; DNA repair and recombination protein RAD54B antibody; EC 3.6.4.- antibody; RAD54 homolog B antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DNA repair and recombination protein RAD54B protein (1-167AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，RAD54B Antibody (CSB-PA896748LA01HU)，的標記方式是Non-conjugated。對于RAD54B Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA896748LB01HU	RAD54B Antibody, HRP conjugated	ELISA
FITC	CSB-PA896748LC01HU	RAD54B Antibody, FITC conjugated
Biotin	CSB-PA896748LD01HU	RAD54B Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group.
基因功能參考文獻：
1. High RAD54B expression is associated with hepatoma. PMID: 29956808
2. Review of structural aspects of RAD54B, molecular functions associated with its cellular roles in preventing genome instability, and how aberrant function contributes to oncogenesis. PMID: 28295846
3. RAD54B expression has potential to serve as a novel prognostic biomarker, particularly for distant recurrence in colorectal cancer PMID: 26046797
4. Patients with expression of both FEN1 and RAD54B were prone to have advanced nodal involvement and significantly poor prognosis. PMID: 26431531
5. The scaffolding function of Rad54B dynamically regulates the maintenance of genome integrity by limiting checkpoint strength. PMID: 25384516
6. support a model in which RAD54L and RAD54B counteract genome-destabilizing effects of direct binding of RAD51 to dsDNA in tumor cells PMID: 25765654
7. RAD54B-deficient cells are selectively killed relative to controls via siRNA-based silencing of SOD1 PMID: 24002644
8. RAD54B and GREB1 gene polymorphisms may not be associated with PCOS in the Han Chinese population. PMID: 23876972
9. These results suggest that hINO80 assists double-strand break repair by positively regulating the expression of the Rad54B and XRCC3 genes. PMID: 20687897
10. Rad54B is a DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54 PMID: 11884632
11. Rad54B enhanced the DNA strand-exchange activity of Dmc1 by stabilizing the Dmc1-single-stranded DNA complex. PMID: 16945962
12. the loss of heterozygosity (LOH) in the 8q12-q24.1 chromosomal region, containing RAD54B gene isn't predictive for breast cancer PMID: 17585536
13. S100A11 targets Rad54B to sites of DNA DSB repair sites and has a role in p21-based regulation of cell cycle PMID: 18463164
14. RAD54B binding may affect the quaternary structure of DMC1. PMID: 18718930
15. RAD54B-deficient human colorectal cancer cells are sensitive to synthetic lethal killing by reduced FEN1 expression, while isogenic RAD54B proficient cells are not PMID: 19218431
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亞細胞定位：

Nucleus.
蛋白家族：

SNF2/RAD54 helicase family
組織特異性：

Abundantly expressed in testis and spleen. Relatively low levels observed in thymus, prostate, ovary and colon.
數據庫鏈接：

HGNC: 17228

OMIM: 604289

KEGG: hsa:25788

STRING: 9606.ENSP00000336606

UniGene: Hs.30561

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