RAB5C Antibody

說明書

中文名稱：

RAB5C兔多克隆抗體
貨號：

CSB-PA019215DSR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA019215DSR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA019215DSR1HU at dilution of 1:100
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RAB5C Polyclonal antibody
Uniprot No.：

P51148
基因名：

RAB5C
別名：

L1880 antibody; RAB; member of RAS oncogene family like antibody; RAB5C antibody; RAB5C; member of RAS oncogene family antibody; RAB5C; member RAS oncogene family antibody; RAB5C_HUMAN antibody; RAB5CL antibody; RAB5L antibody; RABL antibody; Ras-related protein Rab-5C antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ras-related protein Rab-5C protein (1-216AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Protein transport. Probably involved in vesicular traffic.
基因功能參考文獻：
1. We identify RAB5C as a new candidate gene for type-2 diabetes risk with a functional role in endosomal type-2 diabetes module. Functional analysis shows that RAB5C is tyrosine phosphorylated. Data analysis reveals a tyrosine phosphorylation motif in the GTP binding site of RAB5C which may be targeted by insulin receptor. Insulin-dependent tyrosine phosphorylation of RAB5C is inhibited by overexpression of HACD3 (PTPLAD1). PMID: 30300385
2. Enforced miR-509 expression in NALM6 cells reduced RAB5C mRNA and protein levels, and RAB5C was demonstrated to be a direct target of miR-509. PMID: 25368993
3. PLP2 and RAB5C are binding partners of TPD52. PMID: 24604726
4. Rab5C modulates Rac1-mediated cell motility. PMID: 24587345
5. GTP-Rab5c also bound to AMAP1, and activation of Rab5c by EGFR signaling was necessary to promote the intracellular association of AMAP1 and PRKD2 PMID: 22734003
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亞細胞定位：

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome.
蛋白家族：

Small GTPase superfamily, Rab family
數據庫鏈接：

HGNC: 9785

OMIM: 604037

KEGG: hsa:5878

STRING: 9606.ENSP00000345689

UniGene: Hs.650382

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