QARS Antibody
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中文名稱：QARS兔多克隆抗體
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貨號：CSB-PA019132DSR1HU
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規格：￥440
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圖片：
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Western blot
All lanes: Glutamine--tRNA ligase antibody at 2μg/ml
Lane 1: PC-3 whole cell lysate
Lane 2: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 88, 87 kDa
Observed band size: 88 kDa -
Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA019132DSR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA019132DSR1HU at dilution of 1:100 -
Immunoprecipitating QARS in Hela whole cell lysate
Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA019132DSR1HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: CSB-PA019132DSR1HU (4μg) + Hela whole cell lysate (500μg)
Lane 3: Hela whole cell lysate (20μg)
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) QARS Polyclonal antibody
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Uniprot No.：
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基因名：QARS
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別名：GlnRS antibody; Glutamine tRNA ligase antibody; Glutamine tRNA synthetase antibody; Glutamine--tRNA ligase antibody; Glutaminyl tRNA ligase antibody; Glutaminyl tRNA synthetase antibody; Glutaminyl-tRNA synthetase antibody; PRO2195 antibody; QARS antibody; SYQ_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Glutamine--tRNA ligase protein (1-250AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC, IP
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 IP 1:200-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Glutamine--tRNA ligase. Plays a critical role in brain development.
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基因功能參考文獻：
- patient's fibroblasts demonstrated markedly reduced QARS amino acylation activity in vitro PMID: 28620870
- hcmv-miR-US4-1 may involve in promoting cell apoptosis and benefiting discharge of infectious virus particles via down-regulation of QARS in HCMV-infected HELF cells. PMID: 27240979
- Pathological mutations mapping in the N-terminal domain alter the domain structure, and decrease catalytic activity and stability of GlnRS, whereas missense mutations in the catalytic domain induce misfolding of the enzyme. PMID: 26869582
- Data indicate compound heterozygous mutations [c.169T>C (p.Tyr57His) and c.1485dup (p.Lys496*)] in QARS, which encodes glutaminyl-tRNA synthetase, in two siblings with early-onset epileptic encephalopathy (EOEE). PMID: 25471517
- interactions between the N-terminal domains of ArgRS and AIMP1 are important for the catalytic and noncatalytic activities of ArgRS and for the assembly of the higher-order MSC protein complex with ArgRS-GlnRS-AIMP1 PMID: 25288775
- results highlight the importance of QARS during brain development and that epilepsy due to impairment of QARS activity is unusually severe in comparison to other aminoacyl-tRNA synthetase disorders PMID: 24656866
- Data indicate that glutaminyl-tRNA synthetase splice variant GlnRSDeltaiABD was present in exosomes extruded from Jurkat cells and functional in protein synthesis. PMID: 24003230
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相關疾病：Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy (MSCCA)
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亞細胞定位：Cytoplasm, cytosol. Cytoplasm.
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蛋白家族：Class-I aminoacyl-tRNA synthetase family
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組織特異性：Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate.
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數據庫鏈接：
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