Phospho-TGFBR3 (T842) Antibody

說明書

中文名稱：

磷酸化-TGFBR3 (T842)兔多克隆抗體
貨號：

CSB-PA050250
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q03167
基因名：

TGFBR3
別名：

Beta glycan antibody; Betaglycan antibody; Betaglycan proteoglycan antibody; BGCAN antibody; TGBR3_HUMAN antibody; TGF beta receptor type 3 antibody; TGF beta receptor type III antibody; TGF-beta receptor type 3 antibody; TGF-beta receptor type III antibody; TGFB R3 antibody; TGFBR 3 antibody; TGFBR3 antibody; TGFR 3 antibody; TGFR-3 antibody; TGFR3 antibody; Transforming growth factor beta receptor III antibody; Transforming growth factor beta receptor III betaglycan 300kDa antibody; Transforming growth factor beta receptor type 3 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Human TGFβ RIII around the phosphorylation site of T842.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:5000

Protocols：

Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
基因功能參考文獻：
1. describe a detailed characterization of TbetaRIII expression in lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naive and central memory T cells PMID: 29050936
2. TGFBR3 and/or MGEA5 rearrangements are much more common in hybrid hemosiderotic fibrolipomatous tumor-myxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas. PMID: 26980036
3. opposing functions for the different GAG modifications on TbetaRIII suggesting that Wnt interactions with the TbetaRIII heparan sulfate chains result in inhibition of Wnt signaling, likely via Wnt sequestration, whereas the chondroitin sulfate GAG chains on TbetaRIII promote Wnt3a signaling. PMID: 27784788
4. Results suggest that high expression levels of alpha-inhibin and beta-glycan transcripts in secretory phase endometrium are associated with a lower chance of achieving pregnancy with in vitro fertilization. PMID: 27628954
5. Results show decreased TbetaRIII expression with hepatocellullar carcinoma (HCC) progression leading to the activation of Smad2 and suggest that TbetaRIII acts as a suppressive factor in regulating the migration and invasion of HCC, by inhibiting Smad2 and Akt pathways. PMID: 26882862
6. Study shows that TbetaRIII expression is significantly decreased in salivary glands adenoid cystic carcinoma (ACC) patients and defines TbetaRIII as a biomarker exerting antitumor action on ACC progression. PMID: 26531330
7. No correlation of loss of heterozygosity at the TGFBR3 locus with clinicopathological parameters suggests that allelic imbalance may be an early genetic event during neoplastic transformation of human endometrium. PMID: 26548418
8. Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 which shares the signaling inhibiting epithelial-mesenchymal transition. PMID: 25728212
9. Data suggest a high potential of plasma sTBFbetarIII as a novel diagnostic and prognostic biomarker in breast cancer. PMID: 26190421
10. rs1192415 of TGFBR3 is associated with primary open angle glaucoma. PMID: 25861811
11. The presence of the index SNP rs1192415 (TGFBR3-CDC7) was associated with visual field progression in POAG (primary open-angle glaucoma) patients. PMID: 26383992
12. Inhibiting ectodomain shedding of TbetaRIII increased TGF-beta responsiveness and abrogated TbetaRIII's ability to inhibit breast cancer cell migration and invasion. PMID: 24966170
13. RS1805110 is not associated with Behcet's disease or idiopathic intermediate uveitis in Caucasian patients. PMID: 25677673
14. data suggest complex or phenotype specific association of cryptorchidism with TGFBR3 and the gubernaculum as a potential target of TGFbeta signaling PMID: 25390077
15. We have found that TbetaRIII is required for migration and invasion in vitro and xenograft growth in vivo. PMID: 24985072
16. These data demonstrate that TbetaRIII regulates BMP-mediated signaling and biological effects, primarily through the ligand sequestration effects of sTbetaRIII in normal and cancerous mammary epithelial cells. PMID: 25077702
17. Proper localization of TGFBRIII is critical for maintenance of epithelial cell polarity and phenotype. PMID: 24870032
18. TGFBR3 co-downregulated with GATA3 is associated with methylation of the GATA3 gene in bladder urothelial carcinoma. PMID: 24124001
19. Report the presence of TGFBR3 and/or MGEA5 rearrangements in pleomorphic hyalinizing angiectatic tumors and the spectrum of related neoplasms. PMID: 24705316
20. Therefore transient overexpression of TGFBR3 may be a novel strategy for nasopharyngeal carcinoma prevention and therapy PMID: 23387308
21. Low TGFBR3 expression is associated with bladder urothelial carcinoma and enhanced in the invasive bladder cancer. PMID: 23835618
22. Cells in contact with basement membrane undergo transient oscillations between two molecular states defined by their TGFBR3- JUND expression. PMID: 24658685
23. TbetaRIII bound FGF2 and exogenous FGFR1, which promoted neuronal differentiation of neuroblastoma cells. TbetaRIII and FGF2 cooperated to induce expression of the transcription factor inhibitor of DNA binding 1 via Erk MAPK. PMID: 24216509
24. These results reveal a novel function of the matricellular protein CCN6 and establish a mechanistic link between CCN6 and TbetaRIII in maintaining acinar organization in the breast. PMID: 23226100
25. Clinically relevant role for TbetaRIII in regulating integrin alpha5 localization, reveal a novel crosstalk mechanism between the integrin and TGF-beta superfamily signaling pathways. PMID: 22562249
26. Polymorphisms in the betaglycan gene, a co-receptor mediating functional antagonism of activin signalling, significantly predict antidepressant drug treatment outcome in a system-wide pharmacogenetics study in depression. PMID: 23092981
27. a differential regulation of Smads and TGF-beta receptors PMID: 22927969
28. Variations in TGFBR3 gene appear not to be associated with Marfan syndrome or related phenotype. PMID: 22300218
29. Novel missense mutations in the TGFBR3 gene are associated with premature ovarian failure in Chinese women. PMID: 22036907
30. rs1805110 CC genotype in TGFBR3 is probably associated with the protection from BD. The tested two TGFBR3 SNPs are not associated with VKH disease. PMID: 22440163
31. TGFBR3 mutations may be responsible for the genetic aetiology of idiopathic premature ovarian failure in Chinese patients. PMID: 21756058
32. Markers located in the region of TGFBR3 and BMP7 showed association with all testicular dysgenesis syndrome phenotypes in both the discovery and replication cohorts PMID: 22140272
33. TGFBR3 polymorphisms and its haplotypes might be associated with hepatitis B virus clearance and age of hepatocellular carcinoma occurrence. PMID: 21829018
34. Chromosomal translocation t(1;10) is consistent with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor. PMID: 21717526
35. These data support a model whereby TbetaRIII mediates TGF-beta superfamily ligand-induced colon cancer progression and support a context-dependent role for TbetaRIII in regulating cancer progression. PMID: 21847367
36. type III transforming growth factor-beta protein expression is decreased in human multiple myeloma specimens. PMID: 21411633
37. Polymorphisms of ATOH7, TGFBR3 and CARD10 influence the size of optic disc area. PMID: 21307088
38. endometrial cancer is associated with disruption of accessory receptor betaglycan expression, what may alter TGFbeta2-induced signaling. PMID: 21261473
39. TGFBR3 is associated with acute lung injury in mice PMID: 21297076
40. Association of genetic variants in TGFBR3 and asthma in a Korean population. PMID: 20386084
41. Reduced expression of TGFBR3 was observed in non-small cell lung cancer(NSCLC) cell lines, especially in 95D, suggesting that TGFBR3 might play an important role in development and progression of NSCLC. PMID: 20677641
42. Use of sucrose-density ultracentrifugation to isolate membrane-raft fractions demonstrates recruitment of both TGFBbeta receptor (TGFbetaR)II and TGFbetaRI to non-raft membrane fractions by TGFbetaRIII. PMID: 20406198
43. Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma. PMID: 20208565
44. report demonstrates the aberrantly increased expression of betaglycan mRNA in polycystic ovary syndrome ovaries; mechanism by which betaglycan contributes to the pathologic process of PCOS remains to be clarified PMID: 20178540
45. A review on the role of TbetaRIII as a suppressor of cancer progression and/or as a metastasis suppressor. PMID: 20153821
46. Partial plasmin digestion of soluble betaglycan produces two proteolysis-resistant fragments of 45 and 55 kilodaltons (kDa) corresponding, respectively, to betaglucan membrane-distal and -proximal regions. PMID: 19842711
47. endoglin and betaglycan have a critical role in the regulation of TGFbeta signaling in chondrocytes PMID: 12568406
48. Results quantify the relative expression of inhibin alpha, inhibin/activin beta(A), beta(B), beta(C), follistatin, activin receptors and beta-glycan genes in placental tissue of term pre-eclamptic patients. PMID: 12651901
49. analysis of expression and cellular compartmentalization of the activin receptors ActRIIA, ActRIIB and ActRIB, the inhibin co-receptor (betaglycan), and activin signaling proteins Smads 2, 3 and 4, and growth regulatory role during lactation PMID: 12782414
50. findings indicate a physiologically significant, unanticipated role for beta arrestin 2 in regulating TGF-beta signaling through internalization and subsequent decreased signaling of TGF-beta receptors PMID: 12958365
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亞細胞定位：

Secreted. Secreted, extracellular space. Cell membrane; Single-pass type I membrane protein. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.
數據庫鏈接：

HGNC: 11774

OMIM: 600742

KEGG: hsa:7049

STRING: 9606.ENSP00000212355

UniGene: Hs.482390

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