Phospho-PLD1 (S561) Antibody

說明書

中文名稱：

磷酸化-PLD1 (S561)兔多克隆抗體
貨號：

CSB-PA030080
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q13393
基因名：

PLD1
別名：

Choline phosphatase 1 antibody; hPLD1 antibody; Phosphatidylcholine-hydrolyzing phospholipase D1 antibody; Phospholipase D1 antibody; PLD 1 antibody; PLD1 antibody; PLD1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Human PC-PLD1 around the phosphorylation site of S561.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:10000

Protocols：

Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Function as phospholipase selective for phosphatidylcholine. Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic.
基因功能參考文獻：
1. Low PLD1 expression and high ICAT expression were significantly associated with increased survival in colorectal cancer patients. PMID: 28939743
2. findings reveal an unforeseen role for alpha-syn in PLD regulation: PLD1 downregulation may constitute an early mechanism in the initial stages of WT alpha-syn-triggered neurodegeneration. PMID: 29571767
3. The results of this study shown that significant PLD1 down-regulation has been observed in total MS patients compared with controls. PMID: 28229303
4. Simultaneous high expression of PLD1 and Sp1 predicts a poor prognosis for pancreatic ductal adenocarcinoma patients. PMID: 27713167
5. In hearts of PLD1 knockout mice, we detected marked tricuspid regurgitation, right atrial enlargement, and increased flow velocity, narrowing and thickened leaflets of the pulmonic valve. CONCLUSIONS: The findings support a role for PLD1 in normal heart valvulogenesis. PMID: 27799408
6. protein kinase C-epsilon regulation, phospholipase D1 protects retinal pigment epithelium cells from lipopolysaccharide-induced damage PMID: 27793751
7. These findings reveal a novel role of PLD1 in sustaining cancer cell survival during metabolic stress. PMID: 27809301
8. Suggest PLD expression in high grade serous ovarian carcinoma may have a role in mediating progression to effusions and chemoresistance. PMID: 28087476
9. Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells. PMID: 28423060
10. Our data extend the knowledge for a variety of possible roles of PLD1 in allergic disorders including asthma pathogenesis PMID: 26335962
11. These findings reveal a novel role of the PLD1-pleckstrin homology domain as a positive regulator of endocytosis and provide a link between PLD1 and HIF-1alpha in the EGFR endocytosis pathway. PMID: 26680696
12. MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma PMID: 26250158
13. These observations define a novel function of PLD1 as a previously unrecognized HIF-1alpha regulator. PMID: 25361009
14. The impact of polyunsaturated fatty acid (PUFA) supplementation on phospholipase D (PLD) trafficking and activity in mast cells was investigated. PMID: 23698760
15. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism PMID: 25489735
16. Insufficient PLD1 activity, and the associated changes in phospholipid compositions within membranes, may be a factor in impaired autophagic process and protein accumulation in Lewy body diseases. PMID: 24632948
17. Results indicate distinctive roles of phospholipase D PLD1 and PLD2 isoforms in pathological conditions in retinal pigment epithelium (RPE). PMID: 25172550
18. Phospholipase D is involved in the formation of Golgi associated clathrin coated vesicles in human parotid duct cells. PMID: 24618697
19. PLCdelta1 has tumor-suppressive functions in colorectal cancer through E-cadherin induction. PMID: 25197077
20. Downregulation of Chk-alpha with siRNA increased PLD1 expression, and downregulation of PLD1 increased Chk-alpha expression. PMID: 24556997
21. Ectopic expression of PLD1 or PLD2 in human glioma U87 cells increased the expression of hypoxia-inducible factor-1alpha protein. PMID: 25523098
22. Cellular and physiological roles for phospholipase D1 in cancer. PMID: 24990946
23. PlD1 and PLD2 play roles in cell migration, invasion and metastasis. [review] PMID: 24103483
24. Suppression of PLD1 activity prevents FAM83B-mediated transformation. PMID: 23912460
25. The present study indicates that PLD1 plays a role in regulating type I collagen accumulation through induction of autophagy. PMID: 24802400
26. chemokine unresponsiveness in chronic lymphocytic leukemia lymphocytes results from failure of Arf1/phospholipase D1-mediated translocation of Rap1 to the plasma membrane for GTP loading and may be a specific feature of anergy induced by DNA Ags. PMID: 23804711
27. The direct association of PLD1 with the 5-HT2A receptor's carboxy-terminal tail domain displays selective disruption of its PLD signalling pathway. PMID: 23314176
28. These results indicate that PKD is downstream of PLD and suggest that PKD is one of the mechanisms through which PLD promotes aldosterone production in response to AngII in adrenal glomerulosa cells. PMID: 23178798
29. The hydrophobic amino acids involved in the interdomain association of PLD1 are required for vesicular localization and disturbance of its nuclear localization. PMID: 22824913
30. PLD1 in the tumor environment promotes tumor growth and metastasis PMID: 23131846
31. Diacylglycerol stimulates acrosomal exocytosis by feeding into a PKC- and PLD1-dependent positive loop that continuously supplies phosphatidylinositol 4,5-bisphosphate PMID: 22609963
32. PLD acts as an important regulator in Bcl-2 expression by activating STAT3 involving the phosphorylation of Ser727 through the PLA(2)/G(i)/ERK1/2, RhoA/ROCK/p38 MAPK, and Rac1/p38 MAPK pathways. PMID: 22504301
33. Stx1B and Stx2B induce acute VWF secretion in a PLD1-dependent manner but do so by differentially modulating PKCalpha, RhoA, and ADP-ribosylation factor 6. PMID: 22718838
34. Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1. PMID: 22457329
35. amino acids stimulate PLD1 translocation to the lysosomal region where mTORC1 activation occurs in an hVps34-dependent manner, and this translocation is necessary for mTORC1 activation PMID: 22024166
36. Activation of PLD1 contributes to IL-15-mediated osteoclastogenesis via the MAPKs and NF-kappaB signaling pathways in rheumatoid synovial fibroblasts. PMID: 21620893
37. Host cell PLD1 and PLD2 accompanied A. fumigatus conidia during internalization. PMID: 21760893
38. Results indicate PLD activation is required in PMA-stimulated respiratory burst. PMID: 20158570
39. The activation with overexpression of components of the mTORC2-PLD1 pathway in ULMS and to a lesser degree in STUMP provides insight into their tumorigenic mechanisms. PMID: 21326806
40. The PLD1/PA-mTORC2 signal pathway is overactivated in endometrial carcinomas. PMID: 21228924
41. Nuclear localization of phospholipase D1 mediates the activation of nuclear protein kinase C(alpha) and extracellular signal-regulated kinase signaling pathways. PMID: 21113078
42. AMPK-mediated PLD1 activation is required for (14)C-glucose uptake through ERK stimulation PMID: 20231899
43. Data show that formylpeptides induce sequential activation of AKT, ERK1/2, and PLD, which represents a novel signaling pathway. PMID: 20693286
44. PLD isozyme acts as a novel transcriptional target and positive feedback regulator of Wnt signaling, and then promotes Wnt-driven anchorage-independent growth of colorectal cancer cells. PMID: 20711340
45. Data show that there is a functional relationship between phospholipases D1/2 and MAP kinases in the human HeLa carcinoma cell line. PMID: 19896495
46. Platelet-derived growth factor-induced PLD1 expression via NFkappaB may enhance invasiveness of breast cancer cells. PMID: 20188462
47. Upregulated phospholipase D1 is associated with a positive feedback loop to reinforce the Wnt/beta-catenin/TCF signaling in neoplasms PMID: 20442281
48. a novel regulatory mechanism in PLD1 functioning, particularly in the context of subcellular trafficking between different membrane compartments. PMID: 20189990
49. temporal regulation of EGFR endocytosis is achieved by auto-regulatory PLD1 which senses the receptor activation and triggers the translocation of AP2 near to the activated receptor PMID: 19763255
50. alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells PMID: 11821392
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相關疾病：

Cardiac valvular defect, developmental (CVDD)
亞細胞定位：

Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Late endosome membrane; Lipid-anchor; Cytoplasmic side.
蛋白家族：

Phospholipase D family
組織特異性：

Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine.
數據庫鏈接：

HGNC: 9067

OMIM: 212093

KEGG: hsa:5337

STRING: 9606.ENSP00000342793

UniGene: Hs.382865

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