Phospho-HCLS1 (Tyr397) Antibody
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中文名稱：磷酸化-HCLS1 (Tyr397)兔多克隆抗體
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貨號：CSB-PA258754
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規(guī)格：￥2454
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圖片：
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Western blot analysis of extracts from JK cells (Lane 2), using HS1 (Phospho-Tyr397) Antibody.The lane on the left is treated with antigen-specific peptide.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) HCLS1 Polyclonal antibody
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Uniprot No.：
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基因名：HCLS1
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宿主：Rabbit
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反應種屬：Human
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免疫原：Peptide sequence around phosphorylation site of tyrosine 397(G-D-Y(p)-E-E) derived from Human HS1 .
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
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基因功能參考文獻：
- these studies indicate HS1 plays an important role in ROR1-dependent Wnt5a-enhanced chemokine-directed leukemia-cell migration. PMID: 28465529
- SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells. PMID: 25359136
- Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors. PMID: 23017497
- interaction of HCLS1 with LEF-1 is essential for G-CSF-triggered myeloid differentiation; data demonstrate the importance of HCLS1 in myelopoiesis in vitro and in vivo PMID: 23001182
- HS1 overexpressed in leukemic as compared to normal B lymphocytes. PMID: 22768161
- a novel role for HS1 and its phosphorylation during neutrophil directed migration. PMID: 22679023
- High HS1 expression predicts poor survival of chronic lymphocytic leukemia patients. PMID: 22333038
- SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs. PMID: 21287358
- HS1 is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in chronic lymphocytic leukemia. PMID: 20530793
- substrate for caspase cleavage during apoptosis PMID: 11689006
- TBB induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. PMID: 11988074
- found in cell types other than hematopoietic cells PMID: 15754022
- HS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets PMID: 15795233
- The HS1 coiled-coil region acts synergistically with the repeat domain in the modulation of the Arp2/3 complex-mediated actin polymerization. PMID: 16157603
- HS1 may play a role in cytoskeleon organization in B-cells and leukemic B-cells PMID: 17508001
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亞細胞定位：Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion.
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組織特異性：Expressed only in tissues and cells of hematopoietic origin.
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數(shù)據(jù)庫鏈接：
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