Phospho-GRIA1 (Ser849) Antibody

說明書

中文名稱：

磷酸化-GRIA1 (Ser849)兔多克隆抗體
貨號：

CSB-PA580841
規(guī)格：

￥2454
圖片：
Western blot analysis of extracts from Rat brain tissue using GluR1(phospho-Ser849) Antibody.
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GRIA1 Polyclonal antibody
Uniprot No.：

P42261
基因名：

GRIA1
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Peptide sequence around phosphorylation site of serine 849 (Q-Q-S(p)-I-N ) derived from Human GluR1.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
濃度：

It differs from different batches. Please contact us to confirm it.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
基因功能參考文獻(xiàn)：
1. These findings indicate that the CaMKII-mediated GluA1 phosphorylation of S567 and S831 is critical for P2X2-mediated AMPAR internalization and ATP-driven synaptic depression. PMID: 27624155
2. The reversible binding of kynurenic acid (KYNA) on human glutamate receptor (GluR1) polypeptide (GluR1270-300)-modified gold surface has been studied at various temperatures under physiological conditions by two-dimensional SPR experiments. The registered sensorgrams were fitted by using different kinetic models without application of any commercial software. Results suggested that the binding reaction was exothermic. PMID: 27459050
3. Elevated GluA1 expression in spinal cord of the amyotrophic lateral sclerosis patients. PMID: 29367641
4. This study demonstrated that a significant decrease in the protein level of GluA1 in major depression disorder. PMID: 27661418
5. The findings do not support the association of GRIA1 SNPs with schizophrenia in the Chinese Han population. PMID: 26862833
6. Our data of this study confirmed the association of GRIA1 (rs2195450) to female migraine susceptibility in the Chinese Han population. PMID: 26800698
7. Polymorphisms in GRIA1 gene are a risk factor for asparaginase hypersensitivity during the treatment of childhood acute lymphoblastic leukemia PMID: 25697915
8. The level of phosphorylated GluA1 at S831 and S845, two major sites implicated in AMPAR regulation, is almost negligible. Results impel us to reconsider the mechanisms underlying synaptic plasticity. PMID: 25533481
9. This study failed to replicate previously reported association between GRIA1 rs548294 and migraine without aura, either as single marker or when analyzed in haplotype combination with rs2195450. PMID: 24030684
10. the levels were comparable for complexes containing GluR2, GluR3 and GluR4 as well as 5-HT1A. Moreover, the levels of complexes containing muscarinic AChR M1, NR1 and GluR1 were significantly increased in male patients with AD. PMID: 24292102
11. The N-terminal domain modulates alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization. PMID: 24652293
12. insight into the structure and function of the C-terminal domain of GluA1, which controls AMPA receptor function and trafficking during synaptic plasticity in the central nervous system. PMID: 24452473
13. Inhibition of CREB function is associated with a specific reduction of AMPA receptor subunit GluA1. PMID: 23504989
14. Studies indicate that AMPAR trafficking is a key mechanism that drives nascent synapse development, and is the main determinant of both Hebbian and homeostatic plasticity in mature synapses. PMID: 23475111
15. human hippocampal samples from neonatal seizure autopsy cases also showed an increase in GluR1 S831 and S845. PMID: 23223299
16. These results suggest that GRIA1 polymorphism may have influence upon the risk of developing schizophrenia. PMID: 23053966
17. Glioblastoma brain tumor initiating cells express high concentrations of functional calcium-permeable AMPA receptors, raising the possibility that glutamate secretion in the GBM tumor microenvironment may stimulate brain tumor derived cancer stem cells. PMID: 23110111
18. Did not observed any significant association between GRIA1 polymorphisms and clinical improvement in patients with Major depressive disorder. PMID: 22057216
19. SNPs within GRIA1 may not be associated with the development and treatment outcomes in BD PMID: 22122651
20. No significant association GRIA1 polymorphisms was found with the diagnosis of schizophrenia. PMID: 22094384
21. New insights in endosomal dynamics and AMPA receptor trafficking PMID: 21843653
22. AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex PMID: 21856433
23. These results do not support a significant role of GRIA1 or CLINT1 in the development of schizophrenia in the German population. PMID: 21116212
24. analysis of how the AMPA receptor is activated by partial agonists PMID: 21846932
25. These results provide critical new insights into the agonist dependence of both AMPA receptor activation and desensitization and the mechanism of the effects of stargazin on responses of partial agonists. PMID: 21697386
26. by favoring apoCaM binding to AKAP79, KN-62 and KN-93 derail the ability of AKAP79 to efficiently recruit PKC for regulation of GluA1. Thus, AKAP79 endows PKC with a pharmacological profile that overlaps with CaMKII. PMID: 21156788
27. Findings reveal the ligand-binding domain as the critical quality control target in AMPAR biogenesis. PMID: 20837486
28. In transgenic Caenorhabditis elegans, glutamate receptor 1 is required for nose-touch avoidance behavior. PMID: 21037582
29. single-nucleotide polymorphisms annotated to GRIA1 were also significantly associated with allergy to asparaginase PMID: 20592726
30. Two variants in the regulative regions of GRIA1 (rs2195450) and GRIA3 (rs3761555) genes resulted strongly associated with MA (P = 0.00002 and P = 0.0001, respectively), but not associated with MO. PMID: 20579352
31. Increase in GluR1 trafficking by leptin is associated with an increase in phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) levels. PMID: 20237279
32. Modeling of the pore domain of the GLUR1 channel: homology with K+ channel and binding of channel blockers PMID: 11916847
33. Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis. PMID: 12125045
34. a short sequence present in the N-terminal domain has a role in controlling anterograde trafficking of ionotropic glutamate receptors PMID: 12368290
35. kinetics for the opening of the GluR1Qflip channel PMID: 14610080
36. This study investigated whether the AMPA receptor subunit content (GluR1, GluR2, GluR2/3) within "vulnerable" vs. "resistant" sectors of the hippocampus is quantitatively altered with increasing Alzheimer Disease neuropathology PMID: 15144856
37. cell loss and up-regulation of glutamate receptor subunits appear early in temporal lobe epilepsy and contribute to the synaptic plasticity that may facilitate the subsequent sprouting of mossy fiber collaterals PMID: 15145077
38. According to receptor simulations, most differences can be explained if the C-terminal domain is assumed to stabilize the ligand-bound closed and open states. PMID: 15866042
39. Data indicate that GRIA1 may be involved in susceptibility to DSM-IV-TR schizophrenia. PMID: 16526023
40. Results indicate that CTZ and TCM target deactivation and agonist potency independently of desensitization, most likely by modifying agonist dissociation (koff). PMID: 17208968
41. the Q/R site modulates the interaction of stargazin with the transmembrane domains of AMPA receptors via an allosteric mechanism and that this modulation leads to the observed differences in the electrophysiological properties of the receptor PMID: 17483093
42. biochemical study of GLUR1 L497Y AMPA receptor PMID: 17545169
43. AKAP79 provides a mechanism to overcome limitations in kinase abundance thereby ensuring faithful signal propagation and efficient modification of AMPA receptor-mediated responses PMID: 18305116
44. These results suggest that AMPA receptors are abundantly expressed in high-grade gliomas and gene silencing of the GluR1 AMPA receptor subunit results in abrogation of AMPA-mediated signaling and tumor growth. PMID: 18317690
45. combined analysis of all 60 families continued to support evidence for association of GRIA1 with psychotic BP; however, individual SNPs could not be replicated across datasets PMID: 18484081
46. Overexpression of GluR1 positively correlated with glioma cell adhesion to type I and type IV collagen PMID: 18957620
47. Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment PMID: 19536293
48. the intracellularly located CTD of GLUR1 is the origin of TARP-specific functional modulation and not merely a facilitator of trafficking PMID: 19773551
49. Data show that S-nitrosylation of stargazin increases binding to the AMPAR subunit GluR1, causing increased surface expression of the AMPAR. PMID: 19805317
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic density membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
蛋白家族：

Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA1 subfamily
組織特異性：

Widely expressed in brain.
數(shù)據(jù)庫鏈接：

HGNC: 4571

OMIM: 138248

KEGG: hsa:2890

STRING: 9606.ENSP00000285900

UniGene: Hs.519693

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