Phospho-FRS2 (Y436) Antibody

文獻引用 (1) 說明書

中文名稱：

磷酸化-FRS2 (Y436)兔多克隆抗體
貨號：

CSB-PA000714
規格：

￥1090
圖片：
Western Blot analysis of COS cells using Phospho-FRS2 (Y436) Polyclonal Antibody

Western Blot analysis of NIH-3T3 cells using Phospho-FRS2 (Y436) Polyclonal Antibody
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q8WU20
基因名：

FRS2
別名：

FGFR signaling adaptor SNT antibody; FGFR signalling adaptor antibody; FGFR substrate 2 antibody; FGFR-signaling adaptor SNT antibody; Fibroblast growth factor receptor substrate 2 antibody; FRS 2 antibody; FRS2 antibody; FRS2_HUMAN antibody; FRS2A antibody; FRS2alpha antibody; SNT 1 antibody; SNT antibody; SNT-1 antibody; SNT1 antibody; Suc 1 Associated Neurotrophic Factor Target antibody; Suc1 associated neurotrophic factor target 1 antibody; Suc1-associated neurotrophic factor target 1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Monkey
免疫原：

Synthesized peptide derived from Human FRS2 around the phosphorylation site of Y436.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Ganoderma lucidum polysaccharide reduces melanogenesis by inhibiting the paracrine effects of keratinocytes and fibroblasts via IL-6/STAT3/FGF2 pathway Jiang L,journal of cellular physiology,2019

產品評價

靶點詳情

功能：

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
基因功能參考文獻：
1. loss of myristoylation of fibroblast growth factor receptor substrate 2 (FRS2alpha), a scaffold protein essential for FGFR signaling, inhibits FGF/FGFR-mediated oncogenic signaling and FGF10-induced tumorigenesis. Moreover, a previously synthesized myristoyl-CoA analog, B13, which targets the activity of N-myristoyltransferases. PMID: 29540482
2. These findings suggest that FRS2 is amplified consistently in liposarcoma. PMID: 29368794
3. MiR-4653-3p and its target gene FRS2 are may have roles in response of hormone receptor positive breast cancer patients to tamoxifen PMID: 27533459
4. we report for the first time that PKD1 was tightly regulated by androgen at the transcriptional level in prostate cancer cells and was a novel androgen-repressed gene. Further analysis identified FRS2 as a novel mediator of androgen-induced PKD1 repression. PMID: 28077787
5. They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies. PMID: 26096936
6. Results identify FRS2 as an oncogene in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications. PMID: 25368431
7. Increased expression of FRS2alpha (and FGFR1) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma treated with sorafenib. PMID: 25900027
8. The signaling complex appears to integrate the input from FGFR and EphA4, and release the output signal through FRS2alpha. PMID: 20184660
9. These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development. PMID: 24284065
10. The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling. PMID: 24706887
11. Patient with pigmentation disorders and vitiligo show decreased expression of mRNA. PMID: 22151832
12. Data indicate that the FGFR/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas. PMID: 23393200
13. Validated FRS2 amplification in both Well-differentiated liposarcoma and dedifferentiated liposarcoma. PMID: 21793095
14. Microdeformations produced by the combination of polyurethane foam and suction are associated with increased fibroblast proliferation and up-regulation of gene expressions in fibroblasts PMID: 21233699
15. Phosphorylation of Fibroblast growth factor receptor substrate 2alpha may function as a molecular switch in the FGF pathway, sensing and participating in crosstalk with other signaling pathways. PMID: 19652666
16. FRS2 has a role in fibroblast growth factor-2-induced signaling PMID: 12571252
17. findings support a broader role of FRS2 in EGFR-controlled signaling pathways in A-431 cells and provide insight into a molecular mechanism for ligand-stimulated feedback regulation with FRS2 as a central regulatory switch point PMID: 12974390
18. Bisindolylmaleimide I does not inhibit FGF2-induced tyrosine phosphorylation of Frs2. PMID: 17145761
19. an important function for FRS2 is to concentrate RET in membrane foci, leading to an engagement of specific signaling complexes localized in these membrane domains PMID: 18189271
20. a dual mechanism where deletion of the 770YXXL773 motif promotes FGFR2 IIIb C3 transforming activity by causing aberrant receptor recycling and stability and persistent FRS2-dependent signaling. PMID: 19103595
21. Mechanical wounding induces significant ROS generation at the wound edge which, in turn, induced ligand-independent KGFR and FRS2 activation via c-Src kinase signaling. PMID: 19111446
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亞細胞定位：

Endomembrane system. Note=Cytoplasmic, membrane-bound.
組織特異性：

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
數據庫鏈接：

HGNC: 16971

OMIM: 607743

KEGG: hsa:10818

STRING: 9606.ENSP00000299293

UniGene: Hs.593446

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