Phospho-Ets1 (Thr38) Antibody

說明書

中文名稱：

磷酸化-Ets1 (Thr38)兔多克隆抗體
貨號：

CSB-PA294276
規格：

￥2454
圖片：
Western blot analysis of extracts from HepG2 cells using ETS1 (Phospho-Thr38) Antibody.The lane on the right is treated with the antigen-specific peptide.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using ETS1 (Phospho-Thr38) antibody (left)or the same antibody preincubated with blocking peptide (right).

Immunofluorescence staining of methanol-fixed HeLa cells using ETS1 (Phospho-Thr38) Antibody.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Mus musculus (Mouse) Ets1 Polyclonal antibody
Uniprot No.：

P27577
基因名：

Ets1
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Peptide sequence around phosphorylation site of threonine 38(L-L-T(p)-P-S) derived from Human ETS1 .
免疫原種屬：

Mus musculus (Mouse)
克隆類型：

Polyclonal
純化方式：

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC,IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:1000
IHC	1:50-1:100
IF	1:100-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
基因功能參考文獻：
1. miR-326 may target the Ets-1 protein to contribute to iodide-induced thyroiditis, providing a new theoretical basis for the use of miRNA targeting therapy for the treatment of autoimmune diseases. PMID: 29181619
2. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center PMID: 28637900
3. data reveal ETS1 as a critical regulator of ILC2 expansion and cytokine production and implicate ETS1 in the regulation of Id2 at the inception of ILC2 development. PMID: 27069114
4. Ets1 predominantly binds distal nucleosome-occupied regions in double negative thymocytes and nucleosome-depleted regions in double positive thymocytes. importantly, Ets1 induces chromatin remodeling by displacing H3K4me1-marked nucleosomes. PMID: 26673693
5. reduced lung levels of PPARgamma and increased levels of microRNA-27a (miR-27a), v-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS1), endothelin-1 (ET-1), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 and E selectin). PMID: 27612006
6. data support a general model in which Ets-1 interacts with nonspecific DNA via dynamic electrostatic interactions, whereas hydrogen bonding drives the formation of well-ordered complexes with specific DNA PMID: 27362745
7. Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in type 2 diabetes. PMID: 26564177
8. Akt2 upregulates dendritic cell migration at least in part by ETS1-dependent stimulation of IP3R2 transcription. PMID: 24496246
9. The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 and FLI1. PMID: 26093983
10. our data suggested that ESE1/ELF3 may promote the UC progression via accelerating NF-kappaB activation and thus facilitating IEC apoptosis. PMID: 25926267
11. maintenance of appropriate c-ets-1 levels is essential to prevent loss of self-tolerance in the B cell compartment. PMID: 26355157
12. Data indicate interactions between Ets1 transcription factor and two of its important regulators: Lyn, which maintains Ets1 expression to limit the differentiation of autoreactive plasma cells (PCs), and Btk. PMID: 26209625
13. our results demonstrate that both Ets1 and miR-155 can directly regulate the expression of CD1d on B-cells PMID: 25929465
14. Ets-1 has a role in fibronectin-derived heparin-binding domain polypeptides alleviating melanoma cell invasiveness and chemoresistance PMID: 24816403
15. MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation PMID: 24968297
16. Ets-1 overexpression is associated with invasiveness in breast cancer. PMID: 24706481
17. Data show that proto-oncogene protein Ets1 is downregulated in B cells by B cell receptor signaling. PMID: 24929000
18. Mediator of neointima formation in arteriovenous fistula PMID: 24203999
19. The aim of this study was to examine whether expression of microRNA 222 in males and females contributes to changes in the expression of eNOS. PMID: 23632416
20. Data indicate that differences between the N termini of transcription factors Ets1 and Ets2, rather than differences in the DNA binding domains, determine whether the proteins are capable of blocking antibody-secreting cells (ASCs) formation or not. PMID: 24277931
21. Ets-1 promotes the expression of IL-2 by modulating the activity of NFAT. PMID: 24019486
22. ETS1 prevents the binding of ELK3 to EBS2 at low cell density. PMID: 23708702
23. E-twenty-six (ETS) transcription factors Ets related gene (Erg) and Ets1 are the most common sites for transposon insertion in SB-induced JAK2V617F-positive erythroleukemias PMID: 23533276
24. These results suggest a critical role for Ets-1 regulation during B cell activation and cell cycle entry. PMID: 23216019
25. TNF is able to upregulate LT-beta expression in hepatic cells at the transcriptional level by the binding of NF-kappaB p50/p65 heterodimers and Ets1 to their respective sites in the LT-beta promoter. PMID: 22742857
26. microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway PMID: 23060436
27. Data suggest that erythroblastosis virus E26 oncogen homolog-1 (ETS-1) is a common mediator of the proinflammatory and profibrotic effects of Ang II-induced hypertensive renal damage. PMID: 22966006
28. ETS1 regulates a broad gene expression program in NK cells that promotes target cell recognition while limiting cytokine-driven activation. PMID: 22608498
29. miR-370 directly regulates BMP-2 and Ets1 expression, at the translational level, during BMP-2-stimulated cell differentiation. PMID: 22587915
30. Ets-1 is critical for IgG2a CSR and acts as an essential cofactor for Stat1 in the regulation of T-bet expression in B cells. PMID: 22438254
31. An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. PMID: 22297719
32. A physical interaction between Ets-1 and histone deacetylase (HDAC)1 cooperatively downregulates interleukin (IL)-10 gene expression in T helper type (Th)1 cells. PMID: 22266280
33. The activity of Gata4 cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS sites. PMID: 22056786
34. The unstructured N-terminus provides 10-fold uniform stabilization of the ground state ERK2*Ets*MgATP complex and intermediates of the enzymatic reaction. PMID: 21494553
35. Ets-1 directly binds to and activates the CD127 promoter and is a critical regulator of CD127 expression in T cells. PMID: 21148801
36. Data reveal that elevated expression of Ets1 has a much broader array of pro-tumorigenic effects on epithelial cells than previously appreciated. PMID: 20930145
37. Down-regulation of miR-208 in BMP-2-stimulated osteoblast differentiation is an important part of the regulatory machinery involved in early osteogenesis. PMID: 20576608
38. results suggest that Ets-1 activated by the Erk pathway promotes chondrogenic specification and p70S6k activated by both the Erk and Akt pathways plays an important role in gliogenic specification PMID: 20085809
39. the dynamic helical elements of Ets1, appended to a conserved structural core, constitute a phospho-switch that directs Ras/MAPK signaling to downstream changes in gene expression PMID: 20534573
40. Results demonstrate that Ets1 is required to direct the proper migration and differentiation of cardiac neural crest in the formation of the interventricular septum, and could play a role in the etiology of human congenital heart disease. PMID: 20356956
41. Deletion of ETS-1 causes ventricular septal defects and abnormal ventricular morphology in mice. PMID: 19942620
42. the role of antigen strength-dependent Erk1/2 activation for Ets-1-mediated collaboration with IL-12 in CD8+ T cells. PMID: 19843578
43. increase in ETS1 mRNA and protein expression after exposure to electromagnetic fields PMID: 11887334
44. identification of promoter region and binding site for Ets-1 in mouse SERCA3 PMID: 12119294
45. HIF-2alpha and Ets-1 binding is required for transcriptional activation of Flk-1 in endothelial cells PMID: 12464608
46. expression of dominant-negative mutant perturbs normal and tumor angiogenesis in a mouse ear model PMID: 12660815
47. Ets1 has a role in controlling fgl2 expression in endothelial cells PMID: 12752447
48. data suggest that p42Ets-1 acts as a distinct transcription factor from p51Ets-1 PMID: 14668797
49. Ets-1 up-regulation is involved in the development of retinal neovascularization PMID: 15111329
50. ETS-1, PEA3, and ERM have roles in regulation of caveolin-1 transcription in epithelial cells PMID: 15138262
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

ETS family
數據庫鏈接：

KEGG: mmu:23871

STRING: 10090.ENSMUSP00000034534

UniGene: Mm.292415

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