Phospho-ETS1 (S251) Antibody

說明書

中文名稱：

磷酸化-ETS1 (S251)兔多克隆抗體
貨號：

CSB-PA008153
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P14921
基因名：

ETS1
別名：

Avian erythroblastosis virus E26 (v ets) oncogene homolog 1 antibody; C ets 1 protein antibody; c-ets-1 antibody; ETS 1 antibody; Ets protein antibody; ETS proto-oncogene 1; transcription factor antibody; ETS1 antibody; ETS1 oncogene antibody; ETS1 protein antibody; ETS1_HUMAN antibody; EWSR 2 antibody; EWSR2 antibody; FLJ10768 antibody; Oncogene ETS1 antibody; P54 antibody; Protein C-ets-1 antibody; v ets avian erythroblastosis virus E2 oncogene homolog antibody; v ets avian erythroblastosis virus E2 oncogene homolog 1 antibody; v ets avian erythroblastosis virus E26 oncogene homolog 1 antibody; v ets erythroblastosis virus E26 oncogene homolog 1 antibody; v-ets erythroblastosis virus E26 oncogene homolog 1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Human Ets-1 around the phosphorylation site of S251.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:40000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
基因功能參考文獻：
1. enhanced ETS factor activity and the transcription of ETS family target genes related to spliceosome function and cell death induction via alternate MCL1 splicing, is reported. PMID: 29118074
2. ETS1 protein renders its DNA binding targets extremely susceptible to ultraviolet damage in vitro. PMID: 29980679
3. The MAPK-driven CEACAM1p activity is mediated by ETS1. PMID: 29558679
4. High ETS1 expression is associated with cervical cancer. PMID: 30106442
5. Ets-1 is induced by BRAF or MEK kinase inhibition, resulting in increased NRAS expression, which could be blocked by inactivation of Usp9x. PMID: 28198367
6. demonstrated that the interaction of Ets-1 with DNA-PK was mediated through the Ku70 subunit and was mapped to the C-terminal region of Ets-1 and the C-terminal part of Ku70 including SAP domain PMID: 29912634
7. Results show thatproto-Oncogene Protein ets-1 (ETS1) drives ovarian cancer (OC) metastasis phenotypes through its transcriptional target PTK2 (focal adhesion kinase FAK). PMID: 29174800
8. High ETS-1 expression is associated with Colorectal Cancer. PMID: 29802700
9. Results showed that apo(a) and Ets1 were differentially expressed in SMMC7721 and HepG2 cell lines. Meanwhile, apo(a) and Ets1 were inversely correlated with several hepatic endogenous miRNAs, such as miR-125b-5p, miR-23b-3p, miR-26a-5p, and miR-423-5p, which were predicted to bind to Ets1. PMID: 29064597
10. depending on the microenvironment conditions and endogenous miR-125b levels, bone-metastatic cells might switch from Ets-1-dependent motility towards colonization/growth, regulated by the balance between Ets-1 and HIF-1. PMID: 29337876
11. ETS1 polymorphism was suggested to be associated with granulomatosis with polyangiitis and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a Japanese population. PMID: 29167552
12. Results indicated that miR-193a-3p suppressed gastric growth and motility, at least partly, by directly targeting cyclin D1 (CCND1) and ETS proto-oncogene 1 (ETS1) expression. PMID: 29848678
13. Data indicate that in glioblastoma, ETS proto-oncogene 1 (ETS-1)-expression is not dependent on hypoxia, but correlates with tumor vascularization. PMID: 29848683
14. DOT1L cooperates with transcription factor ETS-1 to stimulate the expression of VEGFR2, thereby activating ERK1/2 and AKT signaling pathways and promoting angiogenesis. PMID: 27626484
15. ETS-1 plays oncogenic roles through inducing cell migration and invasion in human bladder cancer PMID: 27036016
16. endothelial master transcription factor ETS1 promotes global RNAPII pause release, and that this process is governed by VEGF PMID: 28851877
17. Data show that SOX9 regulates CEACAM1 primarily via Sp1 and ETS1. PMID: 26885752
18. The present study thus demonstrates that phosphorylation of ETS-1 is a critical event in the DNA polymerase iota-induced invasion and metastasis of esophageal squamous cell carcinoma ( PMID: 28905458
19. DDC up-regulated MMP-1 in LX-2 cells through the Akt and ERK/miR-222/ETS-1 pathways. PMID: 27412967
20. ETS-1 is a molecular target of miR-144-3p, and silencing ETS-1 expression inhibited FaDu and Hep2 cell invasion and migration as well as reduced Hep2 xenograft tumor volume. PMID: 26826553
21. High ETS1 expression is associated with obesity. PMID: 27164408
22. ZEB1 upregulation by SPRY2 results from the combined induction of ETS1 transcription factor and the repression of microRNAs (miR-200 family, miR-150) that target ZEB1 RNA. Moreover, SPRY2 increased AKT activation by epidermal growth factor, whereas AKT and also Src inhibition reduced the induction of ZEB1. PMID: 26455323
23. Ets1 induces ZEB expression and activates the ZEB1 promoter. PMID: 28247944
24. Interaction with ZMYND11 mediates opposing roles of Ras-responsive ETS1 and ETS2. PMID: 28119415
25. a novel mechanism of miR-29b regulation by MAPK-driven ETS1 expression which leads to downstream changes in TET1-mediated epigenetic modifications. PMID: 26776158
26. reduced lung levels of PPARgamma and increased levels of microRNA-27a (miR-27a), v-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS1), endothelin-1 (ET-1), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 and E selectin). PMID: 27612006
27. Lipopolysaccharides-induced CDKN2A expression coincided with a 4.5-fold increase in ETS1 (ETS proto-oncogene 1) mRNA, suggesting that ETS1 is involved in regulating CDKN2A This idea was confirmed by RNAi-mediated suppression or genetic deletion of ETS1, which blocked CDKN2A expression and reduced cholangiocyte senescence. PMID: 28184004
28. Ets-1 p27 isoform is cleaved in the same manner as Ets-1 p51 isoform within the exon VII-encoded region, thus generating a stable C-terminal fragment that induces cell death by initiating apoptosis. PMID: 27737766
29. Our results indicated that ETS1 induced autophagy after inhibition of glycolysis, and thus led to comparative decrease of cell viability. These results implied that ETS1 could be a potential target for tumor metabolic therapy. PMID: 27878249
30. Furthermore, mir106a transfection resulted in decreased expression of MMP-2 and diminished binding activity of transcription factor Ets-1 in EJ cells. PMID: 27513725
31. Integrin b6 markedly promoted the proliferation and invasion of pancreatic carcinoma cells and induced ETS1 phosphorylation in an ERK-dependent manner, leading to the upregulation of matrix metalloprotease-9, which is essential for b6-mediated invasiveness of pancreatic carcinoma cells PMID: 26547582
32. SSRP1/Ets-1/Pim-3 signalling is tightly associated with the proliferation, apoptosis, autophagy, invasion and clonogenicity of nasopharyngeal carcinoma cells, and blockage of this signalling facilitates chemosensitivity of the cells to docetaxel. PMID: 27525970
33. MiR-155 regulates the Th17 immune response by targeting Ets-1 in Behcet's disease. PMID: 27156371
34. results provide insight into the regulation of beta1 integrin through miR-199a-5p-mediated Ets-1 silence and will help in designing new therapeutic strategies to inhibit signal pathways induced by miR-199a-5p in breast cancer invasion PMID: 27094578
35. the markers Ets-1 and APAF-1 relative to p53, Ki-67 and PTEN expression in colon adenomas/polyps, were investigated. PMID: 26743285
36. NR4As regulate gene transcription primarily through interaction with distal enhancers that are co-enriched for NR4A1 and ETS transcription factor motifs PMID: 26938745
37. A significant positive correlation was seen between ETS-1 rs73013527 and RA susceptibility. Carriers of the haplotype CCT or TCT for rs4937333, rs11221332 and rs73013527 had decreased risk. No effect was seen for rs10893872, rs4937333 and rs11221332. PMID: 26241881
38. MiR-324-5p suppresses hepatocellular carcinoma cell invasion by counteracting extracellular matrix degradation through post-transcriptionally downregulating ETS1 and SP1. PMID: 26177288
39. Demonstrate that TrkB protects endothelial integrity during atherogenesis by promoting Ets1-mediated VE-cadherin expression and plays a previously unknown protective role in the development of coronary artery disease. PMID: 25633318
40. Manipulation of the miR-221/222-Ets-1-p21 pathway may offer a novel strategy for treatment of endothelial apoptosis. PMID: 25893733
41. As miR-377 was found to be differentially expressed in clear cell renal carcinoma, and in light of the apparent central role of ETS1 in tumor development, these results indicate that miR-377 could be useful for diagnostics, prognostics and therapeutics. PMID: 25776481
42. Data show that proto-oncogene protein ETS1 transiently forms dimers as a consequence of interacting with any DNA sequence. PMID: 26195629
43. Data show that NF-kappa-B p52 subunit (p52) interacts with ets transcription factors ETS1/2 factors at the C250T telomerase (TERT) promoter to mediate TERT reactivation. PMID: 26389665
44. Ets1 expressing cells are specifically targeted by a novel RNA aptamer for targeted delivery of a nano-formulation. PMID: 25639877
45. Direct interactions between C/EBPalpha and ETS-1 were important for high liver-specific expression of ApoF. PMID: 25726912
46. Results provide evidence of an Rb1-dependent Ets1-Zeb1 amplification loop in thymocytes differentiation and tumor invasion. PMID: 25880398
47. Expression of the ETS transcription factor GABPalpha is positively correlated to the BCR-ABL1/ABL1 ratio in CML patients and affects imatinib sensitivity in vitro. PMID: 26072332
48. c-ETS transcription factors appear to be key regulators of MCM4 origin where c-ETS2 seems to promote DNA replication whereas c-ETS1 functions as a negative regulator. PMID: 26365772
49. discover a pathway where ETS1 advances melanoma through the expression of MET via PAX-dependent and -independent mechanisms PMID: 25531327
50. Fentanyl showed anti-tumor like effects on CRC cells, including less cell clone formation and inhibited cell migration and invasion. PMID: 26296467
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

ETS family
組織特異性：

Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.
數據庫鏈接：

HGNC: 3488

OMIM: 164720

KEGG: hsa:2113

STRING: 9606.ENSP00000376436

UniGene: Hs.369438

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