Phospho-EIF4B (S422) Antibody
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中文名稱：磷酸化-EIF4B (S422)兔多克隆抗體
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貨號：CSB-PA011284
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規格：￥1090
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圖片：
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Western Blot analysis of 293 cells using Phospho-eIF4B (S422) Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：2310046H11Rik antibody; AL024095 antibody; C85189 antibody; EIF 4B antibody; eIF-4B antibody; EIF4B antibody; Eukaryotic initiation factor 4B antibody; Eukaryotic translation initiation factor 4B antibody; IF4B_HUMAN antibody; PRO1843 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from Human eIF4B around the phosphorylation site of S422.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
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基因功能參考文獻：
- FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma. PMID: 29483509
- Synthesis of MCL1, an antiapoptotic protein known to play a role in cancer cell survival during cell division, depends on the function of MELK-elF4B signaling. PMID: 27528663
- Together, our data show that mAChRs modulate eIF4B phosphorylation via the ERK1/2 and PKC signaling pathways in SNU-407 colon cancer cells. PMID: 27773818
- Results indicate that eIF4B integrates the signals from Pim and PI3K/Akt/mTOR pathways in Abl-expressing leukemic cells. PMID: 26848623
- MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eIF4B. PMID: 25955794
- S6K1 enhances c-Myc translation efficiency by modulating the phosphorylation of eukaryotic initiation factor eIF4B, which is critical to unwind its structured 5' untranslated region. PMID: 25220053
- eIF4B is the RSK downstream effector responsible for elevated Lamgamma2 as well as MYC protein in neoplastic epithelial cells. PMID: 24205356
- The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus. PMID: 24829357
- eIF4B-driven expression of these key survival proteins is directly correlated with patient outcome, and eIF4B, DAXX and ERCC5 are identified as novel prognostic markers for poor survival in DLBCL PMID: 24135829
- Report EIF4B binding within the IRES domain V of the coxsackie virus B3 mutant strain. PMID: 24063684
- Overexpression of pim-2 may inhibit the apoptosis of prostate cancer cells through phosphorylation of eIF4B, thus promoting tumorigenesis. PMID: 23813671
- our results identify eIF4B as a critical substrate of Pim kinases in mediating the activity of Abl oncogenes PMID: 23749639
- ORF45/RSK axis-induced eIF4B phosphorylation is involved in translational regulation and is required for optimal KSHV lytic replication. PMID: 21994950
- The solution structure of the eIF4B RNA recognition motif (RRM) domain is reported; the core RRM domain provides only a relative weak interaction with RNA targets and appears to require extensions at the N- and C-terminus for high-affinity binding. PMID: 12885229
- eIF4B may mediate some of the effects of the ribosomal protein S6 kinases on translation PMID: 15071500
- data indicate that eIF4B and 4H stimulate the nuclease activity of herpes simplex virus vhs, and they provide evidence that additional mammalian factors are required for targeting to the encephalomyocarditis virus IRES PMID: 15078951
- Phosphorylation of eIF4B on Ser422 by p90 ribosomal protein S6 kinase (RSK) and S6K is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3. PMID: 16763566
- Data show that reduced levels of eIF4B, eIF4H, or polyA-binding protein, also trigger SG formation. PMID: 19369421
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