Phospho-DUSP1 (S359) Antibody

說明書

中文名稱：

磷酸化-DUSP1 (S359)兔多克隆抗體
貨號：

CSB-PA007841
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P28562
基因名：

DUSP1
別名：

CL 100 antibody; CL100 antibody; Dual Specificity Phosphatase 1 antibody; Dual specificity protein phosphatase 1 antibody; Dual specificity protein phosphatase hVH1 antibody; DUS1_HUMAN antibody; DUSP 1 antibody; Dusp1 antibody; HVH1 antibody; MAP kinase phosphatase 1 antibody; Mitogen-activated protein kinase phosphatase 1 antibody; MKP-1 antibody; MKP1 antibody; Protein tyrosine phosphatase CL100 antibody; Protein-tyrosine phosphatase CL100 antibody; PTPN10 antibody; Serine/threonine specific protein phosphatase antibody; VH1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthesized peptide derived from Human MKP-1 around the phosphorylation site of S359.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
基因功能參考文獻：
1. The molecular structure of DUSP1 crystallized as MBP fusion protein has been reported. PMID: 30198887
2. High DUSP1 expression is associated with apatinib resistance by activating the MAPK pathway in gastric cancer. PMID: 29956792
3. SIN attenuated LPS-induced inflammatory injury by regulation of miR-101, MKP-1 and JNK pathway. PMID: 29501764
4. miR-202-3p is upregulated in type 1 gastric neuroendocrine neoplasms (g-NENs) lesions and might play important roles in the pathogenesis of type 1 g-NENs by targeting DUSP1. PMID: 29434446
5. Downregulation of the expression of DUSP1 or protein phosphatase 1 led to a decline in the beta2adrenergic receptormediated dephosphorylation of ERK1/2. PMID: 29257221
6. the expression of DUSP1 was lower in OA FLSs than in normal FLSs, and DUSP1 may inhibit the expression of OA-associated mediators, MMP-13 and COX-2, by suppressing the activation of p38 MAPK and JNK pathways in OA FLSs. PMID: 28983624
7. Curcumin suppressed CXCL5 expression by direct inhibition of IKKbeta phosphorylation, and inhibition of p38 MAPK via induction of negative regulator MKP-1. PMID: 27538525
8. MKP-1 is a redox-regulated master controller of monocyte function and macrophage phenotype. (Review) PMID: 28330703
9. We propose a signaling cascade involving ARID1A, GADD45B and DUSP1 as mediators of the romidepsin effects in GCC cells. PMID: 27572311
10. this work indicates that suppression of JNK1/2 activity by MKP-1 maintains PARP-1 levels and suggests that MKP-1-mediated cisplatin resistance can be bypassed by PARP-1 inhibition. PMID: 28650468
11. Mean morning and evening DUSP1 mRNA levels showed significant increase during Ramadan compared to Shabaan, however, its diurnal rhythm was maintained. Morning IL-1alpha mRNA expression remained significantly higher than in the evening during Ramadan, but was markedly decreased compared to Shabaan. PMID: 28384165
12. Methylation-mediated silencing of the DUSP-1 promoter does not appear to be associated with reduced expression, indicating the involvement of other factors in specific suppression of DUSP-1 in diabetes-associated cardiac hypertrophy. PMID: 28413926
13. Increased MAP2K6, MAP4K3, and DUSP1 gene expressions in post-chemotherapy samples indicate a poor clinical outcome in osteosarcoma patients. PMID: 28112450
14. The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A, CDC25 and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma. PMID: 28801478
15. Dual-specific phosphatase (DUSP1) was found to inhibit gallbladder cancer (GBC) cell proliferation, migration and invasion. PMID: 28129656
16. The results presented here emphasize the importance of MKP-1 as a mediator of therapeutic effects of glucocorticoids in inflammatory lung diseases as well as its potential as a novel anti-inflammatory drug target. PMID: 28299397
17. Our results emphasize the importance of MKP-1 as a potential predictive biomarker for a subset of breast cancer patients with worse outcome and less susceptibility to treatment. PMID: 27599524
18. Collectively, these data indicated that DUSP1 may induce the resistance against paclitaxel through the p38 MAPK-mediated overexpression of p-glycoprotein in human ovarian cancer cells. PMID: 27422607
19. silencing of IL1B plus dexamethasone-induced DUSP1 significantly reduced IRF1 expression. IL1B-induced expression of CXCL10 was largely insensitive to dexamethasone, whereas other DUSP1-enhanced, IRF1-dependent mRNAs showed various degrees of repression. PMID: 27551049
20. dexamethasone-induced DUSP1 acts via p38 MAPK to switch on the mRNA destabilizing function of protein-tristetraprolin to repress pro-inflammatory cytokine secretion from ASM cells PMID: 26825339
21. LPS tolerance interferes with TLR4 signaling by inhibiting Lyn and c-Src phosphorylation and their recruitment to TLR4, while increasing the phosphatase activity and expression of PP2A, PTPN22, PTP1B and MKP1. PMID: 26457672
22. This study shows that RIG-I activation results in MKP-1-mediated inhibition of cell proliferation in melanoma cells via controlling the p38-HSP27, c-Jun and rpS6 pathways PMID: 26829212
23. In E1a expressing non-small cell lung carcinoma cells, upregulation of MKP1 and the subsequent p38MAPK inhibition is required for the induction of chemosensitivity to cisplatin. PMID: 26689986
24. The heparin effects on TNFalpha-induced stress fiber formation and Map kinase signaling depend on increased DUSP1 expression. PMID: 26769965
25. evidence of association between depressive symptom severity and increasing serum MKP-1 levels in women, and decreasing T levels in perimenopausal women. PMID: 26176177
26. MKP-1 can attenuate tamoxifen-induced cell death through inhibiting the JNK signal pathway. PMID: 26329166
27. Progesterone acts via GR to drive MKP-1 expression, which in turn inhibits IL-1beta-dependent c-Jun activation and COX-2 expression. PMID: 26280733
28. Data show that sorafenib inhibited microRNA miR-101 expression and enhanced dual specificity phosphatase 1 (DUSP1) expression and lowered transforming growth factor beta I (TGF-beta) release in M2 macrophage, slowing macrophage-driven hepatocarcinoma. PMID: 26158762
29. DUSP1 overexpression and inhibition of MAPKs prevented IL1B-induced expression of ZFP36, this was associated with increased TNF mRNA expression at 6 h, an effect that was predominantly due to elevated transcription. PMID: 26546680
30. MKP-1 is a MAPK deactivator; thus, by controlling p38 MAPK phosphorylation status in a temporally distinct manner, MKP-1 ensures that TTP is expressed and made functional at precisely the correct time to repress cytokine expression. PMID: 25724669
31. Wild-type but not mutant p53 transcriptionally upregulated DUSP1 via its DNA-binding domain. DUSP1 and p53 might collaborate to suppress tumors in hepatocarcinogenesis via a positive regulatory loop. PMID: 25617504
32. Data (including data from studies in knockout mice) suggest AMPK activation (AMPKa1 or AMPKa2) suppresses inflammation in vascular smooth muscle cells by down-regulation of STAT1 signaling and up-regulation of MKP-1 (dual specificity phosphatase 1). PMID: 25858560
33. DUSP1 is involved in the antiviral host defense mechanism against a HCV infection PMID: 25798824
34. The proliferation of human cervical cancer cells was also inhibited by DUSP1 PMID: 25872469
35. MKP1 recruits to the chromatin in response to DNA damage and correlates with the decrease of H3S10P, whereas MKP1 is released from chromatin during recovery phase of DNA damage response. PMID: 26111828
36. Decreased DUSP1 might be a mechanism responsible for gefitinib resistance. PMID: 25593344
37. Knockdown of MKP-1 abolished the miR-210-inhibition prevention of cell proliferation under hypoxia. PMID: 25044272
38. PDE4 inhibitors augment antiinflammatory effects of beta2-agonists via increased MKP-1 expression in airway smooth muscle cells. PMID: 25296132
39. Deregulation of EGR-1 and/or DUSP-1 in nasal epithelium could be responsible for the prolonged activated transcriptional state observed in vivo in allergic disease. PMID: 25638726
40. DUSP1 upregulation is strongly linked to adiposity and that physical exercise modulates its expression. PMID: 25370852
41. Data suggest that MKP-2 rather than MKP-1 is tamoxifen-regulated and that the elevated expression of MKP-2 in MCF7-TAMR cells potentially functions to restore tamoxifen sensitivity. PMID: 24658355
42. Together, our results clearly establish the role of Dusp1 as a tumor suppressor gene that regulates cancer-associated inflammation. PMID: 25312268
43. Combined inhibition of MKP1 and HER2 enhanced cell killing in breast cancer. Together, our findings identify a new mechanism of resistance in breast tumors and reveal MKP1 as a novel therapeutic target for radiosensitization. PMID: 25377473
44. MKP-1 and MKP-2 stability is regulated by ERK-mediated phosphorylation through a degradation pathway independent of polyubiquitination PMID: 25204653
45. DUSP1 promotes apoptosis in prostate cancer cells through the inhibition of p38 MAPK. PMID: 24080497
46. DUSP1 expression is increased in obstructive sleep apnea and intermittent hypoxia PMID: 24267255
47. Keratoconic corneas are distinguished with high expression of TGF-beta1 and DUSP1. PMID: 24339725
48. Activating MAPK phosphatase-1 (MKP-1). PMID: 24086554
49. DUSP1 plays a transient, often partial, role in the dexamethasone-dependent repression of certain inflammatory genes. PMID: 24692548
50. MKP-1 promoted angiogenic and arteriogenic neovascular growth, potentially through dephosphorylation of histone H3 serine 10 on coding-region DNA to control transcription of angiogenic genes, such as fractalkine. PMID: 24578378
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
組織特異性：

Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.
數(shù)據(jù)庫鏈接：

HGNC: 3064

OMIM: 600714

KEGG: hsa:1843

STRING: 9606.ENSP00000239223

UniGene: Hs.171695

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