PYCR2 Antibody
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中文名稱：PYCR2兔多克隆抗體
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貨號：CSB-PA019116GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：PYCR2
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別名：1810018M05Rik antibody; FLJ54750 antibody; Leftb antibody; OTTHUMP00000035614 antibody; P5C reductase 2 antibody; P5CR 2 antibody; P5CR2 antibody; P5CR2_HUMAN antibody; PYCR 2 antibody; PYCR2 antibody; Pyrroline 5 carboxylate reductase 2 antibody; Pyrroline 5 carboxylate reductase family member 2 antibody; Pyrroline 5 carboxylate reductase isoform antibody; Pyrroline-5-carboxylate reductase 2 antibody; RP4-559A3.4 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Human PYCR2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH. Involved in cellular response to oxidative stress.
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基因功能參考文獻：
- PYCR2-related syndrome represents a clinically recognizable condition in which PYCR2 mutations lead to protein dysfunction. PMID: 27130255
- It was found that silence of PYCR2 resulted in the decrease of proliferative ability and activation of AMPK/mTOR-induced autophagy of A375 cells. PYCR2 silencing also activated AMPK/mTOR pathway in another melanoma cell line, CHL-1. PMID: 26634742
- Silencing of both PYCR1 and PYCR2 completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress. PMID: 26733354
- Hypomyelination and the absence of lax caused by previously reported mutations in the gene encoding PYCR2's isozyme, PYCR1, suggesting a unique and indispensable role for PYCR2 in the human CNS during development. PMID: 25865492
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相關疾病：Leukodystrophy, hypomyelinating, 10 (HLD10)
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亞細胞定位：Cytoplasm. Mitochondrion.
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蛋白家族：Pyrroline-5-carboxylate reductase family
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組織特異性：Detected in erythrocytes (at protein level). Expressed in fetal brain.
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數據庫鏈接：
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