PTPRS Antibody

中文名稱：

PTPRS兔多克隆抗體
貨號：

CSB-PA613393LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA613393LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA613393LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PTPRS Polyclonal antibody
Uniprot No.：

Q13332
基因名：

PTPRS
別名：

Protein tyrosine phosphatase PTPsigma antibody; Protein tyrosine phosphatase receptor type S antibody; Protein tyrosine phosphatase receptor type sigma antibody; Ptprs antibody; PTPRS_HUMAN antibody; PTPSIGMA antibody; R PTP sigma antibody; R-PTP-S antibody; R-PTP-sigma antibody; Receptor-type tyrosine-protein phosphatase S antibody; Receptor-type tyrosine-protein phosphatase sigma antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Receptor-type tyrosine-protein phosphatase S protein (25-128AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PTPRS Antibody (CSB-PA613393LA01HU)，的標記方式是Non-conjugated。對于PTPRS Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA613393LB01HU	PTPRS Antibody, HRP conjugated	ELISA
FITC	CSB-PA613393LC01HU	PTPRS Antibody, FITC conjugated
Biotin	CSB-PA613393LD01HU	PTPRS Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.
基因功能參考文獻：
1. Study identified several CpG sites and specifically several CpGs in the PTPRS and PER3 genes differentially methylated between obese and non-obese children, suggesting a role for DNA methylation concerning development of childhood obesity. PMID: 28614626
2. interaction of receptor type of protein tyrosine phosphatase sigma (RPTPsigma) with a glycosaminoglycan library PMID: 29420785
3. Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis. PMID: 25385546
4. Data demonstrate that synoviocytes are regulated by an RPTPsigma-dependent proteoglycan switch in vivo, which can be targeted for rheumatoid arthritis therapy. PMID: 25995222
5. represents an evolutionarily conserved pDC-specific inhibitory receptor, and is required to prevent spontaneous IFN production and immune-mediated intestinal inflammation PMID: 26231120
6. crystallographic analyses of a shared HSPG-CSPG binding site reveal a conformational plasticity that can accommodate diverse glycosaminoglycans with comparable affinities; HS and analogs induced RPTPsigma ectodomain oligomerization which was inhibited by CS PMID: 21454754
7. Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma. PMID: 22027896
8. Intragenic microdeletions of the EGFR phosphatase PTPRS were found frequently (26%) in head and neck cancers, identifying this gene as a target of 19p13 loss. PMID: 22065749
9. Transgenic zebrafish carrying a promoter-driven expression vector reveal the increased density of olfactory sensory neuron-specific cell synapses. PMID: 21812780
10. Data show that PTPsigma localizes to PtdIns3P-positive membranes in cells, and this vesicular localization is enhanced during autophagy. PMID: 21303930
11. The receptor protein tyrosine phosphatase sigma (RPTPsigma) has now been identified as a receptor for inhibitory chondroitin sulfate proteoglycans. PMID: 20179269
12. Transient overexpression of the short splice variant 3 of RPTPR Sigma conferred alpha-LTX induced secretion to hamster insulinoma (HIT-15) cells. In contrast, the long splice variant 2 was inactive in secretion or in a single cell assay. PMID: 16552719
13. Three SNPs that flank exon 8 are associated with ulcerative colitis. The presence of these SNPs is associated with novel splicing that removes the third immunoglobulin-like domain (exon 9) from the extracellular portion of PTPsigma. PMID: 17614280
14. SNPs rs1143699, rs4807015, and rs1978237 confer an increased risk of developing type 2 diabetes mellitus. PMID: 17893260
15. In colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency PMID: 19000305
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Cell projection, neuron projection. Cell projection, growth cone.
蛋白家族：

Protein-tyrosine phosphatase family, Receptor class 2A subfamily
組織特異性：

Detected in peripheral blood plasmacytoid dendritic cells (at protein level). Detected in all tissues tested except for placenta and liver. Detected in peripheral blood plasmacytoid dendritic cells.
數據庫鏈接：

HGNC: 9681

OMIM: 601576

KEGG: hsa:5802

STRING: 9606.ENSP00000349932

UniGene: Hs.744928

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