PTPRF Antibody

中文名稱：

PTPRF兔多克隆抗體
貨號：

CSB-PA019053LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA019053LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA019053LA01HU at dilution of 1:100

Immunofluorescence staining of HepG2 cells with CSB-PA019053LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PTPRF Polyclonal antibody
Uniprot No.：

P10586
基因名：

PTPRF
別名：

FLJ43335 antibody; FLJ45062 antibody; FLJ45567 antibody; LAR antibody; LAR protein antibody; LARFN5C antibody; LARS antibody; LCA homolog antibody; Leukocyte antigen related (LAR) PTP receptor antibody; Leukocyte antigen related antibody; Leukocyte antigen related PTP receptor antibody; Leukocyte antigen related tyrosine phosphatase antibody; Leukocyte common antigen related antibody; Protein Tyrosine Phosphatase Receptor Type F antibody; Protein tyrosine phosphatase receptor type F polypeptide antibody; Ptprf antibody; PTPRF protein antibody; PTPRF_HUMAN antibody; Receptor linked protein tyrosine phosphatase LAR antibody; Receptor type tyrosine protein phosphatase F antibody; Receptor type tyrosine protein phosphatase F precursor antibody; Receptor-type tyrosine-protein phosphatase F antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Receptor-type tyrosine-protein phosphatase F protein (688-970AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，PTPRF Antibody (CSB-PA019053LA01HU)，的標(biāo)記方式是Non-conjugated。對于PTPRF Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA019053LB01HU	PTPRF Antibody, HRP conjugated	ELISA
FITC	CSB-PA019053LC01HU	PTPRF Antibody, FITC conjugated
Biotin	CSB-PA019053LD01HU	PTPRF Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
基因功能參考文獻(xiàn)：
1. transferred nuclear Overhauser effects (trNOEs) have been employed in the docking program HADDOCK to generate models for the LAR-fondaparinux complex. These models are further analyzed by postprocessing energetic analysis to identify key binding interactions. PMID: 29570275
2. PTPRF may have value as a predictive marker to identify which patients can obtain the greatest benefit from erlotinib in the post-first-line setting. PMID: 26291013
3. Homozygous truncating PTPRF mutation causes athelia. PMID: 24781087
4. PTPRF is down-regulated in hepatocellular carcinoma-facilitated tumor development. PMID: 24470239
5. Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. PMID: 23986473
6. LAR functions as a negative regulator of adipogenesis. PMID: 19910497
7. regulation of expression by cell density through functional E-cadherin complexes PMID: 12095414
8. LAR PTPase domains play distinct functional roles in phosphorylation and dephosphorylation PMID: 12496362
9. LAR as a crucial regulator of the sensitivity of two key insulin signalling pathways to insulin PMID: 15896785
10. Results identify a protein tyrosine phosphatase as a potential substrate of TACE and describe proteolytic processing of PTP-LAR as a means of regulating phosphatase activity downstream and thus under the control of EGFR-mediated signaling pathways. PMID: 16478662
11. Regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. PMID: 17419996
12. LAR and Src are identified as Death-associated protein kinase (DAPK) regulators through their reciprocal modification of DAPK Y491/492 residues and establishes a functional link of this DAPK-regulatory circuit to tumor progression. PMID: 17803936
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相關(guān)疾病：

Aplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2)
亞細(xì)胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Protein-tyrosine phosphatase family, Receptor class 2A subfamily
數(shù)據(jù)庫鏈接：

HGNC: 9670

OMIM: 179590

KEGG: hsa:5792

STRING: 9606.ENSP00000353030

UniGene: Hs.272062

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