PTPN12 Antibody

說(shuō)明書(shū)

中文名稱：

PTPN12兔多克隆抗體
貨號(hào)：

CSB-PA019026LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, NIH/3T3 whole cell lysate, Rat kidney tissue
All lanes: PTPN12 antibody at 7.4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 89, 73, 75 kDa
Observed band size: 89 kDa

IHC image of CSB-PA019026LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PTPN12 Polyclonal antibody
Uniprot No.：

Q05209
基因名：

PTPN12
別名：

Protein tyrosine phosphatase G1 antibody; Protein tyrosine phosphatase non receptor type 12 antibody; Protein-tyrosine phosphatase G1 antibody; PTN12_HUMAN antibody; PTP PEST antibody; PTP-PEST antibody; PTPG1 antibody; Ptpn12 antibody; Tyrosine protein phosphatase non receptor type 12 antibody; Tyrosine-protein phosphatase non-receptor type 12 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human Tyrosine-protein phosphatase non-receptor type 12 protein (539-714AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，PTPN12 Antibody (CSB-PA019026LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于PTPN12 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA019026LB01HU	PTPN12 Antibody, HRP conjugated	ELISA
FITC	CSB-PA019026LC01HU	PTPN12 Antibody, FITC conjugated
Biotin	CSB-PA019026LD01HU	PTPN12 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.
基因功能參考文獻(xiàn)：
1. identified a new phosphorylation-based substrate recognition mechanism of PTPN12 by CDK2, which orchestrated signaling crosstalk between the oncogenic CDK2 and HER2 pathways PMID: 28842430
2. PTPN12 plasmid transfection increased PTPN12 mRNA and protein expressions, suppressed cell proliferation and migration, reduced EGFR level, and enhanced caspase 3 activity compared with control and empty plasmid groups. PMID: 29634414
3. PTPN12, PTPRN and PTPN18 were independent prognostic factors in Hepatocellular Carcinoma. PMID: 29742497
4. Here, solved is a crystal structure of the native PTPN12 catalytic domain with the catalytic cysteine (residue 231) in dual conformation (phosphorylated and unphosphorylated). PMID: 29278368
5. this study, with a relative large population, showed that PTPN12 eQTL SNP may interact with HBV mutation on HCC risk. PMID: 27075395
6. MyoVa-Ca(2+) channel interactions are required for proper long-range axon growth in developing spinal cord in vivo. PMID: 27134172
7. PTP-PEST regulates EphA3 activation both by affecting cytoskeletal remodelling and through its direct action as a PTP controlling EphA3 phosphorylation. PMID: 26644181
8. Study suggests that PTPN12 expression is a valuable prognostic biomarker for non-small cell lung cancer. PMID: 25868976
9. PTPN12 expression decreases in human renal cell carcinoma PMID: 26537073
10. The decrease expression of PTPN12 might be important in conferring a more aggressive behavior in NPC. Thus, PTPN12 expression may be used as a novel independent prognostic biomarker for patients with NPC. PMID: 25663493
11. PTPN12 is potentially a methylation-silenced TSG for breast cancer that may play an important role in breast carcinogenesis and could potentially serve as an independent prognostic factor for invasive breast cancer patients. PMID: 23044628
12. Decreased expression of PTPN12 correlates with tumor recurrence and poor survival of patients with hepatocellular carcinoma. PMID: 24475046
13. these data suggest that PTP-PEST affects epithelial cell motility by controlling the distribution and phosphorylation of p120 and its availability to control Rho GTPase activity. PMID: 24284071
14. The involvement of PTPN12 in the antioxidant response of breast cancer cells suggests that PTPN12 may represent a novel therapeutic target for this disease PMID: 23435421
15. Overexpression of PTPN12 inhibited proliferation and migration in OSCC cells. PMID: 23733313
16. MRNAs of PTPN12, MSH6, and ZEB1 orthologous genes from different animal species have binding sites for hsa-miR-1279 which consist of homologous oligonucleotides encoding similar human oligopeptides PMID: 23957009
17. High expression of PTPN12 is associated with favorable disease free survival in esophageal squamous cell carcinoma patients. PMID: 22429674
18. activated Ras induces extracellular signal-regulated kinase 1 and 2-dependent phosphorylation of PTP-PEST at S571, which recruits PIN1 to bind to PTP-PEST PMID: 21876001
19. Using a genetic screen, study identifies the PTPN12 tyrosine phosphatase as a tumor suppressor in PMID: 21376233
20. PTP-PEST functions as a suppressor of epithelial cell motility by controlling Rho GTPase activity and the assembly of adherens junctions. PMID: 20519451
21. PTP-PEST actively contributes to the cellular apoptotic response and reveal the importance of caspases as regulators of PTPs in apoptosis. PMID: 17130234
22. These data demonstrate that LPXN forms a signaling complex with Pyk2, c-Src, and PTP-PEST to regulate migration of prostate cancer cells. PMID: 17329398
23. No association was detected between individual PTPN12 tag SNPs and GD but preliminary evidence suggests PTPN12 confers an increased risk of mild/moderate ophthalmopathy (NOSPECS classes 2-4) and that PTPN12 interacts with the TSHR. PMID: 17608818
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亞細(xì)胞定位：

Cytoplasm. Cell junction, focal adhesion. Cell projection, podosome.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily
數(shù)據(jù)庫(kù)鏈接：

HGNC: 9645

OMIM: 600079

KEGG: hsa:5782

STRING: 9606.ENSP00000248594

UniGene: Hs.61812

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