PTGR1 Antibody
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中文名稱：PTGR1兔多克隆抗體
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貨號：CSB-PA003169
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規格：￥1090
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圖片：
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Western Blot analysis of HT29 cells using LTB4DH Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：PTGR1
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別名：15-oxoprostaglandin 13-reductase antibody; FLJ99229 antibody; leukotriene B4 12-hydroxydehydrogenase antibody; LTB4DH antibody; MGC34943 antibody; NADP-dependent leukotriene B4 12-hydroxydehydrogenase antibody; PGR1 antibody; PRG-1 antibody; Prostaglandin reductase 1 antibody; Ptgr1 antibody; PTGR1_HUMAN antibody; RP11-16L21.1 antibody; ZADH3 antibody; zinc binding alcohol dehydrogenase domain containing 3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human LTB4DH.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site. May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one. May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles.
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基因功能參考文獻：
- The data indicate that HMGB1-miR-522-3p-PTGR1 axis may be involved in the abnormal resolution of inflammation and suggest that this mechanism might be a target for modulation of chronic inflammatory disorder. PMID: 28088550
- selenium had only a minor influence on prostaglandin reductase 1 (PTGR1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and protein levels PMID: 25179160
- These results situate PtGR-1 as a critical modulator of both the steady state levels and signaling activities of fatty acid nitroalkenes in vivo. PMID: 23878198
- Data show that two genes, LTB4DH and DPYSL3, were confirmed to be candidate genes for the predictor of a good immune response. PMID: 20804502
- restoration of expression in enzyme-negative lung cancer cell lines induces apoptosis and growth inhibition PMID: 19595472
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亞細胞定位：Cytoplasm.
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蛋白家族：NADP-dependent oxidoreductase L4BD family
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組織特異性：High expression in the kidney, liver, and intestine but not in leukocytes.
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數據庫鏈接：
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