PTGDR2 Antibody

說明書

中文名稱：

PTGDR2兔多克隆抗體
貨號：

CSB-PA005651
規格：

￥1090
圖片：
Western Blot analysis of 293 cells using CD294 Polyclonal Antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9Y5Y4
基因名：

PTGDR2
別名：

PTGDR2; CRTH2; DL1R; GPR44; Prostaglandin D2 receptor 2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; G-protein coupled receptor 44; CD antigen CD294
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human CD294.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
基因功能參考文獻：
1. The data indicate that expression of CRTh2 is regulated through the competitive action of GATA3 and NFAT1. PMID: 29969451
2. The frequencies of the AA genotype of the CRTH2 rs545659 SNP and the CC genotype and the C allele of the CRTH2 rs634681 SNP were higher in patients with severe Hashimoto disease than in patients with mild Hashimoto disease. PMID: 29848886
3. prediction of 3D structures for the DP prostaglandin GPCR, based on the GEnSeMBLE complete sampling with hierarchical scoring (CS-HS) methodology PMID: 29268008
4. Report CRTh2 expression on vascular pericytes in the central nervous system and gastric mucosa. PMID: 27103662
5. CRTh2 mediates most prostaglandin D2 pro-inflammatory effects and long receptor residence time of antagonist LAS191859 translates into long-lasting in vivo efficacy. PMID: 27317944
6. CRTH2 plays a pro-inflammatory role in TNBS-induced colitis and Crohn's disease. Eosinophils contribute to the severity of the inflammation, which is improved by a selective CRTH2 antagonist. Serum levels of PGD2 and Delta(12)-PGJ2 were increased in Crohn's disease patients as compared with control individuals. PMID: 26928963
7. this study shows that allergic rhinitis patients increased the amounts of VIP and PGD2 in their nasal secretions in the early phase reaction, however CRTH2 gene expression from leukocytes recovered in their nasal secretions was upregulated only during the late phase reaction PMID: 28222358
8. the CRTH2 expression on thyroid-infiltrating lymphocytes as well as on lymphocytes from peripheral blood was increased in Hashimoto's thyroiditis as compared to controls. PMID: 27872865
9. smaller proportion of group 2 innate lymphoid cells isolated from nondiseased human lung expressed CRTH2 PMID: 25850654
10. Altered expression of chemoattractant CRTH2 on blood basophils and eosinophils in patients with chronic spontaneous urticaria PMID: 26194547
11. Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer. PMID: 26482433
12. Data indicate that in ulcerative colitis, DP2 receptor showed higher expression in neutrophils but lower in monocytes, and CRTH2 receptor was decreased in eosinophils, NK, and CD3(+) T cells but not in monocytes and CD3(+)/CD4(+) T cells. PMID: 24929001
13. Low DP2 prostanoid receptor is associated with gastric cancer progression. PMID: 24922638
14. CRTh2 rs533116 was associated with allergic asthma in White people PMID: 22947041
15. CRTH2 is not expressed on human amniocytes or myocytes and plays no role in the mechanism of 15dPGJ2-mediated inhibition of NF-kappaB PMID: 23226366
16. Confocal images and FACS demonstrated a strong association and co-localization between VIP peptide and CRTH2 molecules PMID: 23168411
17. These data show that prostaglandin D(2) induces human osteoclast apoptosis through activation of CRTH2 and the apoptosis intrinsic pathway. PMID: 22705147
18. we show that CRTH2+ CD4+ T cells may be involved in the enhanced Th2 cell-mediated immunity in IgG4-related lacrimal gland enlargement. PMID: 22627365
19. identify PGH(1) as an important lipid intermediate and novel CRTH2 agonist which may trigger CRTH2 activation in vivo in the absence of functional prostaglandin D synthase. PMID: 22442685
20. This study provides the first clinical evidence that CRTH2 receptors contribute to airflow limitation, symptoms and eosinophilic airway inflammation in asthma. PMID: 21762224
21. DP receptors amplify the biological response to CRTH2 activation and the CRTH2/DP heteromer might represent both a functional signaling unit for PGD(2) and a potential target for development of heteromer-directed therapy for allergic diseases PMID: 21930295
22. The frequencies of the TT genotype of CRTH2 -466T>C were higher than those of the CC/CT genotype in aspirin-exacerbated respiratory disease patients compared to aspirin-tolerant asthma patients PMID: 22101342
23. expression defines IL-25- and IL-33-responsive type 2 innate lymphoid cells PMID: 21909091
24. DP mediates eosinophils through the elevation of intracellular cAMP production but does not change CRTH2 expression; balance between DP and CRTH2 could influence the degree of PGD2-induced eosinophil migration PMID: 21624751
25. DK-PGD-induced CLC/Gal-10 mRNA level can serve as a potential marker for monitoring pharmacodynamic effects of blood exposure to CRTH2 modulating agents PMID: 20858065
26. in immunologically activated nasal polyp tissue, PGD(2) produced by mast cells promotes the migration of Th2 cells through a CRTH2 dependent mechanism. PMID: 19839971
27. The CRTH2 -466T>C polymorphism increases serum and cellular eotaxin-2 production through lowered CRTH2 expression PMID: 19796209
28. CRTH2 was enriched significantly on interleukin (IL)-4+/IL-13+ T cells compared to interferon (IFN)-gamma+ T cells. There were more CRTH2+ T cells in the bronchoalveolar lavage (BAL) of asthmatics vs. controls. PMID: 20491797
29. CRTH2 is GPR44, a G protein-coupled receptor 44. Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking identified a recycling motif. PMID: 20035740
30. Indomethacin may exert its therapeutic effect in eosinophilic pustular folliculitis (Ofuji's disease) by reducing CRTH2 expression, as well as by inhibiting PGD2 synthesis. PMID: 20107720
31. CRTH2 is involved in mediating some of the therapeutic and/or unwanted side effects of indomethacin, independently of cyclooxygenases and peroxisome proliferator-activated receptors. PMID: 11801628
32. Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. PMID: 12230502
33. data show that 11-dehydro-thromboxane B(2) is a full agonist of the chemoattractant receptor-homologous molecule expressed on TH2 cells(CRTH2) receptor and hence might cause CRTH2 activation in cellular contexts PMID: 14668348
34. CRTH2 protein structure and expression (review) PMID: 15065763
35. Sequence variants of CRTH2 are associated with asthma and differentially influence mRNA stability. PMID: 15345705
36. restoration of CRTH2/CCR3 expression may be an indicator for optimal recovery after septic shock PMID: 15507393
37. selective effect of other PGD2 metabolites on CRTH2 PMID: 15789622
38. analysis of prostaglandin D2 receptor CRTH2 determinants of ligand binding affinity and selectivity PMID: 16030019
39. Data show that the prostaglandin PGD(2) metabolite, 9alpha,11beta-PGF(2), and its stereoisomer, PGF(2alpha), are CRTH2 chemoattractant receptor agonists. PMID: 16378605
40. PGD(2) exerts its effects partly through CRTH2. The PGD(2)/CRTH2 system mediates the chemotaxis of eosinophils, basophils, & Th2 cells involved in the induction of allergic inflammation. Human bronchial epithelial cells express CRTH2. PMID: 17541272
41. These data further emphasize the importance of CRTH2 in eosinophil function (recruitment, respiratory burst, and granulation). PMID: 17714552
42. D-type prostanoid (DP) receptors comediate with CRTH2 the mobilization of eosinophils from bone marrow and their chemotaxis, which might provide the rationale for DP antagonists in the treatment of allergic disease PMID: 17878378
43. demonstrated GATA-3 binding to a probe from the CRTh2 promoter PMID: 17910949
44. relationship between G1544C and A1651G SNPs and serum IL-13 levels in Chinese children patients with asthma PMID: 18777142
45. These results suggest that expression of DP and CRTH2 is associated with the pathophysiology of chronic rhinosinusitis, and the expression of these receptors may be regulated by h-PGDS and PGD. PMID: 18802357
46. PGH2 causes activation of the PGD2 receptors CRTH2 and DP via a dual mechanism: by interacting directly with the receptors and/or by giving rise to PGD2 after catalytic conversion by plasma proteins. PMID: 18835884
47. CRTH2 inhibition by its C terminus may represent a rather unappreciated strategy employed by a GPCR to specify the extent of G protein activation PMID: 19010788
48. CRTH2 expressions of leukocytes in allergic nasal mucosa are significantly up-regulated compared with those in nonallergic nasal mucosa suggesting that CRTH2 may play an important role in the recruitment of leukocytes into allergic nasal mucosa PMID: 19230460
49. The CRTH2 -466T>C gene polymorphism may not affect on the phenotype of chronic urticaria, but controbutes to the required dose of antihistamines in patients. PMID: 19290788
50. Genetic variation within CRTh2 modifies the development of allergic sensitization and asthma in a population of German children. PMID: 19392992
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, e
數據庫鏈接：

HGNC: 4502

OMIM: 604837

KEGG: hsa:11251

STRING: 9606.ENSP00000332812

UniGene: Hs.299567

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