PSPH Antibody
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中文名稱：PSPH兔多克隆抗體
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貨號：CSB-PA018938ESR1HU
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規格：￥440
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圖片：
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Western blot
All lanes: PSPH antibody at 3.81µg/ml
Lane 1: HL60 whole cell lysate
Lane 2: A431 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 25 kDa
Observed band size: 25 kDa -
Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA018938ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018938ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PSPH Polyclonal antibody
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Uniprot No.：
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基因名：PSPH
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別名：EC 3.1.3.3 antibody; L 3 phosphoserine phosphatase antibody; L-3-phosphoserine phosphatase antibody; O phosphoserine phosphohydrolase antibody; O-phosphoserine phosphohydrolase antibody; Phosphoserine phosphatase antibody; Phosphoserine phosphatase deficiency; included antibody; PSP antibody; PSPase antibody; Psph antibody; PSPHD antibody; SERB_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Phosphoserine phosphatase protein (1-225AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine (Probable).
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基因功能參考文獻：
- PSPH expression is a novel biomarker for poor prognosis and could play an important role in tumor progression of colorectal cancer. PMID: 28476802
- We further uncovered that phosphoserine phosphatase (PSPH), the final rate-limiting enzyme of the SSP pathway, is critical for cMyc-driven cancer progression both in vitro and in vivo PMID: 25793315
- study of an intellectual disability family from Pakistan; identified a variant in PSPH: chr7:56088803C>T, NM_004577.3 c.103G>A; p.Ala35Thr (hg19) which segregated in homozygous form with the phenotype in both branches of the family PMID: 25080166
- phosphoserine phosphatase deficiency is associated with Neu-Laxova syndrome. PMID: 25152457
- status of PSPH in normal skin epidermis and skin tumors along with its sub-cellular localization in epidermal keratinocytes and its requirement for squamous cell carcinoma proliferation PMID: 21726982
- purification, crystallization and preliminary X-ray diffraction analysis PMID: 11752790
- description of the first crystal structures of the HPSP in complexes with the competitive inhibitor 2-amino-3-phosphonopropionic a PMID: 12213811
- human phosphoserine phosphatase structure now shows a sevenfold coordinated Ca(2+) ion in the active site that might explain the inhibitory effect of Ca(2+) on the enzyme PMID: 15291819
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相關疾病：Phosphoserine phosphatase deficiency (PSPHD)
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亞細胞定位：Cytoplasm, cytosol.
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蛋白家族：HAD-like hydrolase superfamily, SerB family
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數據庫鏈接：
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