PSMB5 Antibody

中文名稱：

PSMB5兔多克隆抗體
貨號(hào)：

CSB-PA010083LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Mouse lung tissue
All lanes: PSMB5 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 29, 22, 18 kDa
Observed band size: 29 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA010083LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA010083LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA010083LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PSMB5 Polyclonal antibody
Uniprot No.：

P28074
基因名：

PSMB5
別名：

DKFZp459C139 antibody; EC 3.4.25.1 antibody; LMPX antibody; Macropain epsilon chain antibody; MB1 antibody; MGC104214 antibody; MGC118075 antibody; MGC134464 antibody; Multicatalytic endopeptidase complex epsilon chain antibody; Proteasome (prosome, macropain) subunit, beta type, 5 antibody; Proteasome beta 5 subunit antibody; Proteasome catalytic subunit 3 antibody; Proteasome chain 6 antibody; Proteasome epsilon chain antibody; Proteasome subunit beta type-5 antibody; Proteasome subunit MB1 antibody; Proteasome subunit X antibody; Proteasome subunit, beta type, 5 antibody; Proteasome subunit, beta-5 antibody; PSB5_HUMAN antibody; PSMB5 antibody; PSX large multifunctional protease X antibody; X antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human Proteasome subunit beta type-5 protein (106-188AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，PSMB5 Antibody (CSB-PA010083LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于PSMB5 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA010083LB01HU	PSMB5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA010083LC01HU	PSMB5 Antibody, FITC conjugated
Biotin	CSB-PA010083LD01HU	PSMB5 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
基因功能參考文獻(xiàn)：
1. Our results suggest a potential role for PSMB5 as a biomarker and therapeutic target for Triple-negative breast cancer PMID: 28623645
2. Results identified PSMB5 Q62P mutation to underlie bortezomib resistance in Down-syndrome-associated acute myeloid leukemia cells. PMID: 28143565
3. Data indicate that proteasomal subunit X PSMB5 is a target of signal transducer and activator of transcription 3 (STAT3). PMID: 24627483
4. Nuclear MB1 expression was an independent predictor of worse survival in ovarian cancer. PMID: 19243813
5. critical role of PSMB5 in 20S proteasome-mediated protection against replicative senescence, pointing to a possible strategy for maintaining the integrity of culture-expanded bone marrow stromal cells by manipulating the expression of PSMB5 PMID: 24393841
6. The expression of proteasome beta5 decreases markedly in human atherosclerotic plaques. PMID: 22781773
7. Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1, PSMB5, PSMB6, PSMB8, PSMB9, and PSMB10. PMID: 23018640
8. Letter/Case Reports: proteasome subunit beta5t is expressed in cervical ectopic thymoma. PMID: 22523338
9. PSMB5 overexpression is associated with Bortezomib resistance in myeloma. PMID: 21978467
10. No mutations or differences in PSMB5 mRNA expression were seen before bortezomib treatment in 3 multiple myeloma patients, but after treatment, 1 patient showed PSMB5 upregulation associated with bortezomib resistance. PMID: 21920470
11. CDK5 regulation of proteasome subunit PSMB5 was identified as a probable route to antineoplastic drug sensitization. PMID: 21289309
12. Expression of mutated PSMB5 was associated with the prevention of the accumulation of unfolded proteins PMID: 20555361
13. interaction of TAP1 and TAP2 and P-glycoprotein with proteasome subunits beta-5 and beta-5i suggest direct targeting of antigenic peptides to the ER via a TAP-proteasome association and a possible role for P-glycoprotein PMID: 15488952
14. Proteasome activity can be genetically "upregulated" in lens cells by overexpression of beta5 catalytic subunit. Resulting increase in proteasome activity leads to decrease in oxidized proteins and enhanced cell survival following oxidative stress. PMID: 17262013
15. G322A mutation of the PSMB5 gene is a novel mechanism for bortezomib resistance. PMID: 18502982
16. nonsynonymous coding single nucleotide polymorphismsin the proteasome beta 5 subunit gene did not show significant effects on proteasome activity, but SNPs did influence transcription PMID: 18519783
17. Overexpression of PSMB5 is an important mechanism for bortezomib resistance in Jurkat cell lines. PMID: 18562081
18. a novel mechanism of bortezomib resistance associated with the selective overexpression of a mutant PSMB5 protein PMID: 18565852
19. Mutations of the PSMB5 gene resulting in substitutions of Ala49 and Ala50 of PSMB5 protein can confer varying bortezomib resistance PMID: 19426847
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亞細(xì)胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Peptidase T1B family
數(shù)據(jù)庫鏈接：

HGNC: 9542

OMIM: 600306

KEGG: hsa:5693

STRING: 9606.ENSP00000355325

UniGene: Hs.422990

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