PSMA4 Antibody

中文名稱：

PSMA4兔多克隆抗體
貨號：

CSB-PA018869LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA018869LA01HU at dilution of 1:100

Immunofluorescent analysis of A549 cells using CSB-PA018869LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PSMA4 Polyclonal antibody
Uniprot No.：

P25789
基因名：

PSMA4
別名：

HC9 antibody; HsT17706 antibody; Macropain subunit C9 antibody; MGC111191 antibody; MGC12467 antibody; MGC24813 antibody; Multicatalytic endopeptidase complex subunit C9 antibody; Proteasome (prosome macropain) subunit alpha type 4 antibody; Proteasome alpha 4 subunit antibody; Proteasome component C9 antibody; Proteasome subunit alpha type 4 antibody; Proteasome subunit alpha type-4 antibody; Proteasome subunit HC9 antibody; Proteasome subunit L antibody; PSA4_HUMAN antibody; PSC9 antibody; PSMA 4 antibody; psmA4 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Proteasome subunit alpha type-4 protein (148-184AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PSMA4 Antibody (CSB-PA018869LA01HU)，的標記方式是Non-conjugated。對于PSMA4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA018869LB01HU	PSMA4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA018869LC01HU	PSMA4 Antibody, FITC conjugated
Biotin	CSB-PA018869LD01HU	PSMA4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
基因功能參考文獻：
1. Five of these SNPs acted as cis-eQTLs, being associated with the transcription of IREB2 (rs2568494, rs16969968, rs11634351, rs6495309), PSMA4 (rs6495309) and ERCC1 (rs735482), out of 10,821 genes analyzed in lung. For these three genes, we obtained experimental evidence of differential allelic expression in lung tissue, pointing to the existence of in-cis genomic variants that regulate their transcription. PMID: 28181565
2. rs12901682 is associated with lung cancer risk in a Chinese Han population. PMID: 25744645
3. study concludes polymorphisms of TGM5, PPAP2B and PSMA4 are not major contributors tonon-small cell lung cancer susceptibility in never-smoking hinese population, this primarily can be attributed to the significantly distinct genetic background of Asian populations from western populations PMID: 24518713
4. Unexpected interaction between alpha4 and alpha7 subunits may provide a molecular basis for the formation of previously reported 13S and 16S assembly intermediates. PMID: 15225636
5. Parkin interacts with the proteasome subunit alpha4 PMID: 15987638
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Peptidase T1A family
數據庫鏈接：

HGNC: 9533

OMIM: 176846

KEGG: hsa:5685

STRING: 9606.ENSP00000044462

UniGene: Hs.251531

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