PRRX1 Antibody

說明書

中文名稱：

PRRX1兔多克隆抗體
貨號：

CSB-PA003862
規格：

￥1090
圖片：
Western Blot analysis of Jurkat cells using PRX1 Polyclonal Antibody

Western Blot analysis of Jurkat cells using PRX1 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P54821
基因名：

PRRX1
別名：

AGOTC antibody; Homeobox protein PHOX1 antibody; Paired mesoderm homeo box 1 antibody; Paired mesoderm homeobox 1 antibody; paired mesoderm homeobox 1 isoform pmx-1b antibody; Paired mesoderm homeobox protein 1 antibody; Paired related homeobox 1 antibody; Paired related homeobox protein 1 antibody; Paired-related homeobox protein 1 antibody; PHOX 1 antibody; PHOX1 1, 2 antibody; PHOX1 antibody; PMX 1 antibody; PMX1 antibody; PRRX 1 antibody; Prrx1 antibody; PRRX1_HUMAN antibody; PRX 1 antibody; PRX-1 antibody; PRX1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human PRX1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer.
基因功能參考文獻：
1. Low PRRX1 expression is associated with hepatocellular carcinoma. PMID: 28677793
2. identified a functional genetic variant that alters PRRX1 expression, ultimately resulting in electrophysiological alterations in atrial myocytes that may promote Atrial fibrillation. PMID: 28974514
3. The glioma-initiating cells self-renewal function regulated by PRRX1 is mediated by dopamine D2 receptor (DRD2). PRRX1 directly binds to the DRD2 promoter and transactivates its expression in glioma-initiating cells. PMID: 28486630
4. LGR5-expressing fraction of CD54+ cells represents gastric cancer CSCs, in which LGR5 is closely associated with stemness and EMT core genes PMID: 28033430
5. Prrx1b may be an important regulator of epithelial-mesenchymal transition in Triple-negative breast cancer cells. PMID: 27027510
6. miR-655 inhibits the acquisition of the epithelial-mesenchymal transition phenotype in triple-negative breast cancer by down-regulating Prrx1, thereby inhibiting cell migration and invasion during cancer progression. PMID: 26820102
7. Decreased Expression of PRRX1 was Associated with Hepatocellular Carcinoma. PMID: 25404478
8. the switch from Prrx1b to Prrx1a governs EMT plasticity in both mouse models of PDAC and human PDAC PMID: 26773005
9. These findings demonstrate that PRRX1 promotes epithelial-mesenchymal transition in gastric cancer cells PMID: 25428393
10. Our results indicate that activation of Notch signaling by PRRX1 is associated with the promotion of glioblastoma cell invasion. PMID: 25522823
11. We conclude that miR-146b-5p has a role in cell proliferation and invasion, and that PRRX1 plays an important role in papillary thyroid carcinoma epithelial-mesenchymal transition and disease progression. PMID: 24946010
12. Overexpression of PRRX1 in stably overexpressed-miR-124 cell lines could rescue the effects of radiosensitivity enhancement brought by miR-124. PMID: 24705396
13. In the rare variant joint analysis, damaging variants within the PRRX1 region showed significant association with AF. PMID: 24239840
14. PRRX1 is an indicator of metastasis and poor prognosis in colorectal cancer cases. PMID: 23807160
15. The homeobox factor Prrx1 is an EMT inducer conferring migratory and invasive properties. PMID: 23201163
16. We show that the homeobox factor Prrx1 is an EMT inducer conferring migratory and invasive properties. The loss of Prrx1 is required for cancer cells to metastasize in vivo, which revert to the epithelial phenotype concomitant with the acquisition of stem cell properties. PMID: 23201163
17. Mutation analysis was performed after sequencing the entire coding regions of OTX2 and PRRX1 genes isolated from the proband and his parents. After thorough analysis, no DNA variations were detected. PMID: 22198066
18. identification of the two Prx1 target genes, which play a pivotal role in development of liver fibrosis, is a novel finding for liver pathophysiology PMID: 18296734
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相關疾?。?/div>
Agnathia-otocephaly complex (AGOTC)
亞細胞定位：

Nucleus.
蛋白家族：

Paired homeobox family
數據庫鏈接：

HGNC: 9142

OMIM: 167420

KEGG: hsa:5396

STRING: 9606.ENSP00000239461

UniGene: Hs.283416

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