PRND Antibody

說明書

中文名稱：

PRND兔多克隆抗體
貨號：

CSB-PA890741ESR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA890741ESR2HU at dilution of 1:100
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PRND Polyclonal antibody
Uniprot No.：

Q9UKY0
基因名：

PRND
別名：

dJ1068H6.4 antibody; DPL antibody; Dublet antibody; MGC41841 antibody; Prion gene complex downstream antibody; Prion like protein doppel antibody; Prion protein 2 (dublet) antibody; Prion protein 2 antibody; Prion-like protein doppel antibody; PRND antibody; PRND_HUMAN antibody; PrPLP antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Prion-like protein doppel protein (20-160AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required for normal acrosome reaction and for normal male fertility. Can bind Cu(2+).
基因功能參考文獻：
1. results demonstrate that blocking doppel can control VEGF signaling in TECs and selectively inhibit tumor angiogenesis. PMID: 26950422
2. The association between the APOE, CYP46, PRNP and PRND genes and the profile of neuropsychiatric symptoms in Polish subjects with Alzheimer's disease and mild cognitive impairment, was evaluated. PMID: 22453181
3. in astrocytomas, Dpl undergoes different molecular processes that might constitute additional helpful tools to characterize the glial tumor progression PMID: 20981146
4. Cytotoxicity induced by the expression of Dpl and truncated PrP in neural derived cells are closely related with the apoptosis process. PMID: 19728151
5. expression pattern and biochemical characteristics in human tissues and in Chinese hamster ovary cells transfected with wild-type or variant human Dpl gene constructs PMID: 12200435
6. Doppel expression is not modified in the brains of patients with Creutzfeldt-Jakob disease. PMID: 12586339
7. human Doppel fails to interact with itself; Dpl and PrP are not related or are only marginally related with respect to their ligand binding behaviour PMID: 15158907
8. results demonstrate that Doppel and PrPc co-patch extensively at the plasma membrane PMID: 15203115
9. Doppel interacts with the full-length laminin receptor precursor protein PMID: 15246873
10. Doppel is expressed early during ontogenesis, and is found in both germ cells and Sertoli cells. Doppel may play a physiological role in acrosome biogenesis. PMID: 16421231
11. Extensive differences in PRND gene expression were also found within each grade of malignancy, suggesting that PRND mRNA quantitation might be useful to distinguish astrocytoma subtypes. PMID: 17390034
12. Study provides the foundation for further study of Dpl biological functions in vitro and in vivo. PMID: 17894227
13. Results might suggest a potential and functional role for Dpl in tumor cells migratory and morphological behaviours and address to future gene-targeted therapeutic interventions. PMID: 18936526
14. results suggested that the function of Dpl is antagonistic to PrP rather than synergistic PMID: 19129949
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

Prion family
組織特異性：

Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).
數據庫鏈接：

HGNC: 15748

OMIM: 604263

KEGG: hsa:23627

STRING: 9606.ENSP00000306900

UniGene: Hs.406696

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