PPP3CB Antibody
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中文名稱：PPP3CB兔多克隆抗體
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貨號：CSB-PA018573GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：Calcineurin A beta antibody; Calcineurin A2 antibody; Calcineurin B; formerly antibody; Calmodulin dependent calcineurin A subunit beta isoform antibody; Calmodulin-dependent calcineurin A subunit beta isoform antibody; CALNA 2 antibody; CALNA2 antibody; CALNB antibody; CAM PRP catalytic subunit antibody; CAM-PRP catalytic subunit antibody; CNA2 antibody; CnAbeta antibody; PP2BB_HUMAN antibody; PP2Bbeta antibody; PPP3CB antibody; Protein phosphatase 2B; catalytic subunit; beta isoform; formerly antibody; Protein phosphatase 3 (formerly 2B) catalytic subunit beta isoform antibody; Protein phosphatase 3 catalytic subunit beta isoform antibody; Protein phosphatase 3 catalytic subunit beta isozyme antibody; Serine/threonine protein phosphatase 2B catalytic subunit beta isoform antibody; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human PPP3CB
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.
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基因功能參考文獻：
- The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients PMID: 27907007
- ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function. PMID: 21531385
- The expression of a constitutively active Calcineurin stimulates myoblast differentiation, whereas a Calcineurin antisense has the opposite effect. PMID: 21664352
- A novel-splicing variant of calcineurin Ass CnAss-FK, which is encoded by an intron-retaining mRNA and is deficient in the autoinhibitory domain, is predominantly expressed in mature follicular keratinocytes. PMID: 21423799
- [review] The nuclear localization sequence, a region spanning amino acids 172-183 of calcineurin A beta, is essential for recognition and shuttling of calcineurin into the nucleus by importin beta. PMID: 19925438
- calcineurin regulates AUF1 posttranslationally in vitro and PTH gene expression in vivo but still allows its physiological regulation by calcium and phosphate PMID: 15514034
- depressed NCX activity might contribute to the etiology of in vivo cardiac hypertrophy and dysfunction occurring under conditions in which both calcineurin and protein kinase C are chronically activated PMID: 15557343
- Calcineurin A beta expression is an additional means of regulating calcineurin activity in the heart. PMID: 16024800
- Data show that the calcineurin pathway is activated in hypertrophic myocardium as demonstrated by increased calcineurin activity and expression of calcineurin A-beta and B, and GATA-4, and a shift of cytoplasmic NFAT-3 into the nucleus. PMID: 18034994
- We describe a case of Calcineurin inhibitor-mediated bilateral hippocampal injury after bone marrow transplantation. PMID: 18458866
- TAK1-TAB1-TAB2 selectively induces calcineurin-NFAT signalling through direct phosphorylation of RCAN1, while calcineurin activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1. PMID: 19136967
- calcineurin is inhibited by cyclosporine A, which then exerts multiple effects on human melanoma cell lines HT168 and WM35 PMID: 19287956
- calcineurin can dephosphorylate GSK-3beta at Ser-9 and form a stable complex with GSK-3beta, suggesting the possibility that calcineurin regulates the dephosphorylation and activation of GSK-3betain vivo PMID: 19659461
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亞細(xì)胞定位：Cytoplasm.
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蛋白家族：PPP phosphatase family, PP-2B subfamily
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數(shù)據(jù)庫鏈接：
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