PPP2R5E Antibody

中文名稱：

PPP2R5E兔多克隆抗體
貨號：

CSB-PA619075LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA619075LA01HU diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA619075LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PPP2R5E Polyclonal antibody
Uniprot No.：

Q16537
基因名：

PPP2R5E
別名：

2A5E_HUMAN antibody; Epsilon isoform of regulatory subunit B56 protein phosphatase 2A antibody; PP2A B subunit B' epsilon antibody; PP2A B subunit B' epsilon isoform antibody; PP2A B subunit B56 epsilon antibody; PP2A B subunit B56 epsilon isoform antibody; PP2A B subunit isoform B''-epsilon antibody; PP2A B subunit isoform B'-epsilon antibody; PP2A B subunit isoform B56-epsilon antibody; PP2A B subunit isoform PR61-epsilon antibody; PP2A B subunit isoform R5-epsilon antibody; PP2A B subunit PR61 epsilon antibody; PP2A B subunit PR61 epsilon isoform antibody; PP2A B subunit R5 epsilon antibody; PP2A B subunit R5 epsilon isoform antibody; PPP2R5E antibody; Protein phosphatase 2 regulatory subunit B (B56) epsilon isoform antibody; Protein phosphatase 2 regulatory subunit B' epsilon antibody; Protein phosphatase 2 regulatory subunit B' epsilon isoform antibody; Regulatory subunit B of protein phosphatase 2 epsilon isoform antibody; Serine/threonine protein phosphatase 2A 56 kDa regulatory subunit epsilon antibody; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform protein (2-149AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PPP2R5E Antibody (CSB-PA619075LA01HU)，的標記方式是Non-conjugated。對于PPP2R5E Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA619075LB01HU	PPP2R5E Antibody, HRP conjugated	ELISA
FITC	CSB-PA619075LC01HU	PPP2R5E Antibody, FITC conjugated
Biotin	CSB-PA619075LD01HU	PPP2R5E Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
基因功能參考文獻：
1. results suggest that the PPP2R5E phosphatase may contribute to microtubule organization by stabilizing MTCL1. PMID: 27521566
2. PP2A holoenzyme containing B56 is responsible for the dephosphorylation of gamma-H2AX and regulation of DNA repair of double strand breaks induced by camptothecin. PMID: 25772433
3. the significance of miR-23a and PPP2R5E in the proliferation and apoptosis of gastric cancer cells PMID: 24997345
4. Downregulation of PPP2R5E affects the oncogenic potential of leukemic cells. PMID: 23812941
5. identified the phosphorylation of hSgo2 by Aurora B at the N-terminal coiled-coil region and the middle region, and showed that these phosphorylations separately promote binding of hSgo2 to PP2A and MCAK PMID: 20889715
6. The PPP2R5E gene is identified as harboring genetic variants that can affect human cancer and are possibly under evolutionary selection pressure. PMID: 19773383
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亞細胞定位：

Cytoplasm.
蛋白家族：

Phosphatase 2A regulatory subunit B56 family
數據庫鏈接：

HGNC: 9313

OMIM: 601647

KEGG: hsa:5529

STRING: 9606.ENSP00000337641

UniGene: Hs.334868

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