PPP1R8 Antibody
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中文名稱：PPP1R8兔多克隆抗體
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貨號：CSB-PA618641DSR2HU
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規格：￥440
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圖片：
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Western blot
All lanes: PPP1R8 antibody at 1.11µg/ml
Lane 1: PC-3 whole cell lysate
Lane 2: HL60 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 39, 23, 14 kDa
Observed band size: 39 kDa -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA618641DSR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA618641DSR2HU at dilution of 1:100 -
Immunofluorescent analysis of HepG2 cells using CSB-PA618641DSR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PPP1R8 Polyclonal antibody
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Uniprot No.：
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基因名：PPP1R8
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別名：Activator of RNA decay antibody; ARD 1 antibody; ARD-1 antibody; ARD1 antibody; Homolog of E.coli RNase E antibody; NIPP 1 antibody; NIPP-1 antibody; NIPP1 antibody; Nuclear inhibitor of protein phosphatase 1 antibody; nuclear inhibitor of protein phosphatase-1 alpha antibody; Nuclear subunit of PP1 antibody; PP1R8_HUMAN antibody; PPP1R8 antibody; PRO2047 antibody; Protein phosphatase 1 regulatory inhibitor subunit 8 antibody; Protein phosphatase 1 regulatory subunit 8 antibody; RNase E antibody; RNase E, E. coli, homolog of antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Nuclear inhibitor of protein phosphatase 1 protein (1-209AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:20-1:200 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.; Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.
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基因功能參考文獻：
- NIPP1 could be activated by hypoxia and contributed to hypoxia-induced invasive and metastatic potential in hepatocellular carcinoma. PMID: 27644248
- Data suggest overexpression of NIPP1 in HeLa cells causes induction of genes of mesenchymal lineage with reduction in cell proliferation; thus, key dephosphorylation events may be involved in epithelial-mesenchymal transition or transdifferentiation. PMID: 25907536
- The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly PMID: 11909864
- NIPP1 has a role in the nuclear targeting and/or retention of PP1 PMID: 15501817
- Required for the global trimethylation of histone3 at lysine27 and is implicated in gene silencing by enhancer of zeste homolog (EZH)2. PMID: 17724462
- NIPP1 is present in a complex with EED and EZH2 in vivo and has distinct binding sites for these proteins. PMID: 17804093
- NMR structure of the NIPP1 FHA domain. PMID: 18253837
- NIPP1 works as a molecular sensor for PP1 to recognize phosphorylated Sap155. PMID: 18842582
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亞細胞定位：Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear.; [Isoform Gamma]: Cytoplasm. Note=Found mainly in the cytoplasm.
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組織特異性：Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform
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數據庫鏈接：
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