POU3F2 Antibody, Biotin conjugated

說明書

中文名稱：

POU3F2兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA018397HD01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) POU3F2 Polyclonal antibody
Uniprot No.：

P20265
基因名：

POU3F2
別名：

Brain 2 antibody; Brain specific homeobox/POU domain protein 2 antibody; Brain-2 antibody; Brain-specific homeobox/POU domain protein 2 antibody; BRN 2 antibody; Brn-2 antibody; BRN2 antibody; N Oct 3 antibody; N OCT 3 Gene antibody; N Oct3 antibody; Nervous system specific octamer binding transcription factor antibody; Nervous system-specific octamer-binding transcription factor N-Oct-3 antibody; OCT 7 antibody; Oct-7 antibody; OCT7 antibody; Octamer Binding Transcription Factor 7 antibody; Octamer-binding protein 7 antibody; Octamer-binding transcription factor 7 antibody; OTF 7 antibody; OTF-7 antibody; OTF7 antibody; PO3F2_HUMAN antibody; POU class 3 homeobox 2, antibody; POU domain class 3 transcription factor 2 antibody; POU domain, class 3, transcription factor 2 antibody; Pou3f2 antibody; POUF 3 antibody; POUF3 antibody; Protein Brn 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human POU domain, class 3, transcription factor 2 protein (1-443AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes.
基因功能參考文獻：
1. Re4sults show that BRN2 is: directly transcriptionally repressed by AR, required for the expression of terminal neuroendocrine markers and aggressive growth of castration-resistant prostate cancer (CRPC), and is highly expressed in human neuroendocrine prostate cancer and metastatic CRPC with low circulating PSA. PMID: 27784708
2. These findings not only shed light on the molecular mechanism of the anticancer properties of capsaicin, but also the transcription regulation of tNOX expression that may potentially explain how POU3F2 is associated with tumorigenesis. PMID: 27271588
3. We show that POU3F2 lies downstreamof SIM1 and controls oxytocin expression in the hypothalamic neuroendocrine preoptic area. We show that this finding is consistent with the expression patterns of POU3F2 and related genes in the human brain. PMID: 26833329
4. TTF1 expression in small-cell lung cancer is a cell lineage-specific phenomenon that involves the developing neural cell-specific homeoprotein BRN2. PMID: 23358112
5. The present study investigated transcriptional regulation of CDH13 in melanoma. Found an inverse correlation between BRN2 and T-cadherin protein and transcript expression in melanoma. PMID: 23069940
6. links BRN2 as an activator and MITF as a repressor of the NOTCH pathway in melanoma cells. Loss of the BRN2-MITF axis in antisense-ablated cell lines decreased the melanoma sphere-forming capability and cell adhesion PMID: 21358674
7. a model for the apparent non-overlapping expression levels of BRN2 and MITF in melanoma, mediated by miR-211 expression. PMID: 21435193
8. POU3F2 may regulate the properties of melanoma cells via autocrine KIT ligand signalling. PMID: 20337985
9. The results suggest that the high levels of Brn-2 expression observed in melanomas link BRAF signaling to increased proliferation. PMID: 15024080
10. Rb induces a proliferative arrest and regulates Brn-2 expression in retinoblastoma cells PMID: 17163992
11. Brn-2 regulates invasiveness and directly represses Mitf expression. PMID: 18829533
12. SOX9 and SOX10 but not BRN2 seem to be required for nestin expression in human melanoma. PMID: 18923447
13. Expression and purification of full-length BRN2, a transcription factor involved in melanoma growth, are reported. PMID: 18996486
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亞細胞定位：

Nucleus.
蛋白家族：

POU transcription factor family, Class-3 subfamily
組織特異性：

Expressed specifically in the neuroectodermal cell lineage.
數據庫鏈接：

HGNC: 9215

OMIM: 600494

KEGG: hsa:5454

STRING: 9606.ENSP00000329170

UniGene: Hs.182505

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