POU3F1 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) POU3F1 Polyclonal antibody
Uniprot No.：

Q03052
基因名：

POU3F1
別名：

class 3 antibody; Oct-6 antibody; OCT6 antibody; Octamer-binding protein 6 antibody; Octamer-binding transcription factor 6 antibody; OTF-6 antibody; OTF6 antibody; PO3F1_HUMAN antibody; POU class 3 homeobox 1 antibody; POU domain antibody; POU domain class 3 transcription factor 1 antibody; POU domain transcription factor SCIP antibody; pou3f1 antibody; SCIP antibody; transcription factor 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human POU domain, class 3, transcription factor 1 protein (59-257AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. Acts as a transcriptional repressor of myelin-specific genes.
基因功能參考文獻：
1. Combined high OATP1A2/high OCT6 may be a potential predictor of response to anthracycline/taxane-based chemotherapy in breast cancer PMID: 24671357
2. CpG island hypermethylation contributes to down-regulation of Oct-6 mRNA expression in hepatocellular carcinoma. PMID: 21448695
3. Our results suggest that Tst-1 and Skn-1a regulate expression of MMPs in keratinocytes and effect both the expression and activation of these proteolytic enzymes. PMID: 17195013
4. Strict control of Pou3f1 transgene expression is critical to proper myelination, and factors responsible for Pouf31 downregulation during myelination may play important roles in the development of peripheral neuropathies. PMID: 17959798
亞細胞定位：

Nucleus.
蛋白家族：

POU transcription factor family, Class-3 subfamily
組織特異性：

Expressed in embryonal stem cells and in the developing brain.
數據庫鏈接：

HGNC: 9214

OMIM: 602479

KEGG: hsa:5453

STRING: 9606.ENSP00000362103

UniGene: Hs.1837

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