POLR2F Antibody

說明書

產品詳情

Uniprot No.：

P61218
基因名：

POLR2F
別名：

POLR2F antibody; POLRF antibody; DNA-directed RNA polymerases I antibody; II antibody; and III subunit RPABC2 antibody; RNA polymerases I antibody; II antibody; and III subunit ABC2 antibody; DNA-directed RNA polymerase II subunit F antibody; DNA-directed RNA polymerases I antibody; II antibody; and III 14.4 kDa polypeptide antibody; RPABC14.4 antibody; RPB14.4 antibody; RPB6 homolog antibody; RPC15 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human POLR2F
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds.
基因功能參考文獻：
1. These results suggest that RPAP2 controls Pol II activity through a direct interaction with Rpb6 PMID: 25639305
2. Solution structure of the hRPABC14.4 subunit of human RNA polymerases.(RPABC14.4 ?) PMID: 10542096
3. POLR2F and PRNP exhibited elevated levels in carcinomas compared to normal tissue samples suggesting a possible role for these molecules in colorectal cancer. PMID: 18505059
亞細胞定位：

Nucleus.
蛋白家族：

Archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family
數(shù)據(jù)庫鏈接：

HGNC: 9193

OMIM: 604414

KEGG: hsa:5435

STRING: 9606.ENSP00000403852

UniGene: Hs.436578

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