POLR1A Antibody
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中文名稱：POLR1A兔多克隆抗體
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貨號：CSB-PA018322GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：POLR1A
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別名：A190 antibody; AFDCIN antibody; DNA-directed RNA polymerase I largest subunit antibody; DNA-directed RNA polymerase I subunit A antibody; DNA-directed RNA polymerase I subunit rpa1 antibody; Polr1a antibody; Polymerase (RNA) I polypeptide A 194kDa antibody; RNA polymerase I 194 kDa subunit antibody; RNA polymerase I subunit A antibody; RNA polymerase I subunit A1 antibody; RPA1 antibody; RPA1_HUMAN antibody; RPA194 antibody; RPO1 4 antibody; RPO14 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Human POLR1A
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
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基因功能參考文獻：
- Data show that BRCA1 interacts directly with the basal RNA polymerase I (Pol-I) transcription factors as well as interacting with RNA Pol-I itself. PMID: 27589844
- Homozygous c.2801C>T (p.(Ser934Leu)) in POLR1A was identified in two brothers with unusual neurological disease that manifested with ataxia, psychomotor retardation, cerebellar and cerebral atrophy, and leukodystrophy. PMID: 28051070
- Consistent with this observation, we discovered that polr1a mutant zebrafish exhibited cranioskeletal anomalies mimicking the human phenotype. polr1a loss of function led to perturbed ribosome biogenesis and p53-dependent cell death PMID: 25913037
- SIRT7 knockdown leads to reduced levels of RNA Pol I protein, but not messenger RNA PMID: 22586326
- findings demonstrate that Bloom's syndrome helicase (BLM)interacts with RPA194; studies suggest that nucleolar BLM modulates rDNA structures in association with RNA polymerase I to facilitate RNA polymerase I-mediated rRNA transcription PMID: 22106380
- Interference of POLR1A inhibited the synthesis of rRNA and hindered cell cycle progression in cells with inactivated p53, as a consequence of downregulation of the transcription factor E2F-1. PMID: 21878508
- analyzed the kinetics of assembly and elongation of the RNA polymerase I complex on endogenous ribosomal genes in the nuclei of living cells with the use of in vivo microscopy [RPA43] PMID: 12446911
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相關疾病：Acrofacial dysostosis, Cincinnati type (AFDCIN)
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亞細胞定位：Nucleus, nucleolus. Chromosome.
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蛋白家族：RNA polymerase beta' chain family
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數據庫鏈接：
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