PNOC Antibody

說明書

中文名稱：

PNOC兔多克隆抗體
貨號：

CSB-PA090243
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA090243(PNOC Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA090243(PNOC Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

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靶點詳情

產品詳情

Uniprot No.：

Q13519
基因名：

PNOC
別名：

N/OFQ antibody; N23K antibody; N23K/N27K antibody; Nociceptin, included antibody; nocistatin antibody; Npnc1 antibody; OFQ antibody; OFQ/N antibody; Orphanin FQ antibody; Orphanin FQ2 antibody; Pnoc antibody; PNOC_HUMAN antibody; ppN/OFQ antibody; PPNOC antibody; pre-pro-N/OFQ antibody; prepronociceptin antibody; pronociceptin antibody; Propronociceptin antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human PNOC
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.; Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.; Has potent analgesic activity.
基因功能參考文獻：
1. found differences in Neonatal Abstinence Syndrome outcomes depending on PNOC and COMT SNP genotype. PMID: 27983768
2. The presence of the PNOC rs732636 A allele was associated with the worse Neonatal abstinence syndrome outcomes in infants. PMID: 26791055
3. Data suggest that nociceptin plays a crucial role in progress of meiosis during spermatogenesis. [REVIEW] PMID: 25677772
4. Data suggest that both nociceptin and nocistatin inhibit myometrial contractions and may play roles in perception of pain during delivery. [REVIEW] PMID: 25677774
5. REVIEW: intracellular localization and physiological role of nociceptin and nocistatin PMID: 23454174
6. Strong expression of PNOC was seen in neoplastic neurons of 7/7 brainstem gangliogliomas, but was significantly weaker in non-brainstem GGs. PMID: 22706982
7. The presence of Orphanin, Oxytocin, ANP, eNOS and iNOS proteins was identified in the human umbilical cord.[Orphanin] PMID: 21744319
8. A high expression of nociceptin in adenomyosis may be one of the casual factors of dysmenorrhea. The severity of dysmenorrhea is positively correlated with the expression of nociceptin in eutopic endometrial tissue. PMID: 21600132
9. chronic ischemic conditions of atherosclerotic origin are associated with significantly lower plasma nociceptin levels PMID: 21310194
10. PNOC expression level was 2.99 times higher in vitiligo involved skin when compared to healthy control skin. PMID: 20888736
11. Results showed that vigorous and prolonged hyperventilation changes plasma nociceptin/orphanin FQ levels due to the direct effects of hypocapnic alkalosis or to different sympatho-adrenergic system responses. PMID: 20100531
12. Peripheral blood levels are elevated in Wilson disease PMID: 12812047
13. results show that nociceptin/NociR is present and functional in human neutrophils, and the results identify a novel dialogue pathway between neural and immune tissues PMID: 12950177
14. The presence of two different forms of mature nocistatin (NST-17 and NST-30) and a possible N-terminal methionine cleaved NST-29 have been confirmed by both radioimmunoassay and mass spectrometry. PMID: 16043263
15. Two SNPs in PNOC showed marginal association with alcoholism and one with illicit drug dependence. PMID: 17910740
16. Peripheral blood mononuclear cells transcribe pre-pro-nociception/orphaninFQ. PMID: 18292431
17. Unstable angina is associated with a significant increase in circulating nociceptin/orphanin FQ levels unrelated to intervening transient myocardial ischemia or hemodynamic changes. PMID: 19560501
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亞細胞定位：

Secreted.
蛋白家族：

Opioid neuropeptide precursor family
組織特異性：

Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.
數據庫鏈接：

HGNC: 9163

OMIM: 601459

KEGG: hsa:5368

STRING: 9606.ENSP00000301908

UniGene: Hs.88218

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