PNLIPRP2 Antibody
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中文名稱：PNLIPRP2兔多克隆抗體
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貨號：CSB-PA018264LA01HU
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規(guī)格：￥440
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圖片：
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Western Blot
Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate
All lanes: PNLIPRP2 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52 kDa
Observed band size: 52 kDa -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018264LA01HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PNLIPRP2 Polyclonal antibody
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Uniprot No.：
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基因名：PNLIPRP2
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別名：EC 3.1.1.3 antibody; Galactolipase antibody; LIPR2_HUMAN antibody; Pancreatic lipase-related protein 2 antibody; PL-RP2 antibody; PLRP2 antibody; Pnliprp2 antibody; Secretory glycoprotein GP 3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Pancreatic lipase-related protein 2 protein (305-460AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，PNLIPRP2 Antibody (CSB-PA018264LA01HU)，的標記方式是Non-conjugated。對于PNLIPRP2 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylate triacylglycerols. When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity. Also has low phospholipase activity. In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids. The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane.
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基因功能參考文獻：
- findings show that endosomal lipases participate in lipid antigen presentation by processing lipid antigens and have a role in T cell immunity against mycobacteria PMID: 27662254
- The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 PMID: 26494624
- Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. PMID: 23732775
- BSSL and PLRP2 hydrolyzed triglycerides (TG) to free FA and glycerol. PMID: 21865348
- Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns PMID: 21652702
- localization of PLRP2 in endosomes of monocytes PMID: 21554982
- Investigation of the substrate specificity of purified recombinant pancreatic lipase-related protein 2 reveals that its physiological role is digestion of galactolipids, the main plant lipids present in the vegetables which are a part of the human diet. PMID: 15287741
- Patients with chronic calcifying pancreatitis (CCP) had significantly lower levels of both pancreatic lipase and PLRP2 than the controls subjects. PMID: 16887271
- finding that the inhibition of nonproteolyzed rHPLRP2 by tetrahydrolipstatin and diethyl-p-nitrophenyl phosphate does not involve any bile salt requirements suggests that the rHPLRP2 lid adopts an open conformation in aqueous media. PMID: 17401110
- Most of the structural and kinetic properties of HPLRP2 were found to be different from those of rat PLRP2 PMID: 18702514
- The pancreatic lipase related protein 2 is required for lipid-dependent cytotoxicity mediated by cytotoxic T lymphocytes. PMID: 19548271
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亞細胞定位：Secreted. Zymogen granule membrane; Peripheral membrane protein. Cell projection, neuron projection.
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蛋白家族：AB hydrolase superfamily, Lipase family
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組織特異性：Pancreas.
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數據庫鏈接：
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