PLCD1 Antibody, FITC conjugated
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中文名稱：PLCD1兔多克隆抗體, FITC偶聯(lián)
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貨號：CSB-PA018130LC01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) PLCD1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：PLCD1 antibody; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 antibody; EC 3.1.4.11 antibody; Phosphoinositide phospholipase C-delta-1 antibody; Phospholipase C-III antibody; PLC-III antibody; Phospholipase C-delta-1 antibody; PLC-delta-1 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 protein (419-653AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. Binds phosphatidylinositol 4,5-bisphosphate.
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基因功能參考文獻(xiàn)：
- A loss of epidermal PLCdelta1 impairs epidermal barrier function through dysregulation of Ca2+ and p38 mitogen-activated protein kinase (MAPK) signaling. This study also reveals a possible link among PLCdelta1 downregulation, p38 MAPK hyperactivation, and barrier defects in psoriasis-like skin inflammation. PMID: 28430185
- PLCD1 acts as a tumour suppressor, by KIF3A-mediated suppression of ERK1/2/beta-catenin/MMP7 signalling, at least in part, in breast cancer. PMID: 28423710
- Nine of the 32 (28.1%) iCCA patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 mutations, two each (6.3%) of CACNA2D3 and RASSF1 mutations, and one each (3.1%) of ATG7 and PLCD1 mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations. PMID: 29122566
- The PLCdelta1 negatively regulates autophagy, and PLCdelta1 suppression contributes to the tolerance of CRC cells harboring KRAS mutations to nutrient deprivation and anti-cancer drug treatment. PMID: 28528980
- Phospholipase C delta 1 is both a KLF15-regulated gene and a novel repressor of airway smooth muscle hypertrophy. PMID: 28375666
- High PLC delta expression is associated with breast cancer. PMID: 28112359
- slow phase of Gi/o-mediated TRPC4 activation was diminished by inhibiting RhoA or enhancing PLCdelta function PMID: 26755577
- Both unsaturated and saturated dioleoyl-phosphatidylinositol-(4,5)-bisphosphate successfully recruited PHPLCdelta1 to cell membranes. PMID: 25995263
- Neuropeptide Y decreased PLCD1 expression in HUVECs. PMID: 24903829
- PLC-delta1 and TRPV6 are critical actor of Ca(2+) homeostasis in CF human bronchial epithelial cells. PMID: 25477137
- Ectopic expression of PLCD1 inhibits breast tumor cell proliferation in vivo by inducing apoptosis and suppressed tumor cell migration by regulating cytoskeletal reorganization. PMID: 25655282
- PLCdelta1 is required for maintenance of homeostasis in skin and metabolic tissues. [review] PMID: 23948486
- Provide evidence for intramolecular interactions in the PLC-delta1 PH domain. PMID: 23388389
- Genotyping using microsatellite markers linked the families to the gene PLCD1 on chromosome 3p22.2. Sequence analysis of the gene detected one novel (p.Ser740ArgfsX19) and one previously reported mutation (p.Arg437X). PMID: 23149345
- A novel mutation in the PLCD1 gene, which leads to an aberrant splicing event, underlies autosomal recessive leuconychia. PMID: 22458588
- PLCD1 acts as a functional tumor suppressor and may serve as a biomarker for possible early detection and prognosis of chronic myeloid leukemia. PMID: 22576628
- Increased PLC-delta1 activity causes enhanced coronary vasomotility such as that seen in patients with coronary spastic angina. PMID: 22265909
- Mutations in this gene cause hereditary porcelain nails. Review. PMID: 22078044
- Significantly deregulated pathways in colorectal cancer were identified and repression of PLCD1 and PLCE1 expression, was validated. PMID: 21909432
- these data show that mutations in PLCD1 underlie hereditary leukonychia, revealing a gene involved in molecular control of nail growth. PMID: 21665001
- PLCD1 is silenced by promoter methylation in breast cancer. Silencing of PLCD1 is reversed by demethylation which leads to the disruption of cell cycle at G2/M phase in breast cancer, indicating that PLCD1 functions as a tumor suppressor in this tumor. PMID: 20657189
- After PLC-delta 1 treatment with small interfering RNA, angiotensin II type 1 receptor-stimulated inositol phosphate formation is attenuated. PMID: 20018811
- Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta PMID: 11960991
- the PLC-delta1 promoter is under the control of NF-kappaB, which mediates the expression of PLC-delta due to Abeta42 PMID: 14550290
- PLCdelta(1) and PLCdelta(4) are probably differentially regulated in distinct cellular compartments by PI(4,5)P(2) PMID: 15037625
- Nuclear translocation of phospholipase C-delta1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate PMID: 15809301
- the Ral-CaM complex defines a multifaceted regulatory mechanism for PLC-delta1 activation PMID: 15817490
- In this review, recent findings regarding the molecular machineries and mechanisms of the nucleocytoplasmic shuttling of PLCdelta1 will be discussed. PMID: 16240320
- These results support the model that activation of selected PLC isoforms at the cleavage furrow controls progression of cytokinesis through regulation of PIP2 levels PMID: 17041247
- PLC delta 1 plays an important suppressive role in the development and progression of esophageal squamous cell carcinoma PMID: 18006814
- Human ARHGAP6 protein possessing GTPase stimulating activity for RhoA on the catalytic properties of PLC-delta1, was studied. PMID: 18434237
- Data are consistent with the idea that phospholipase C d1 and d3 isoforms support the growth and migration of normal and neoplastic mammary epithelial cells in vitro. PMID: 19344632
- PLCD1 acts as a functional tumor suppressor involved in gastric carcinogenesis. PMID: 19448674
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相關(guān)疾病：Nail disorder, non-syndromic congenital, 3 (NDNC3)
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組織特異性：Strongly expressed in lung, liver and heart. Also expressed at least in pancreas, kidney, skeletal muscle, placenta and brain.
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