PLCB3 Antibody
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中文名稱：PLCB3兔多克隆抗體
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貨號：CSB-PA003817
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規格：￥1090
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圖片：
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Western Blot analysis of HepG2 cells using PLC β3 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase beta 3 antibody; 1-phosphatidylinositol-4 antibody; 5-bisphosphate phosphodiesterase beta-3 antibody; Phosphoinositide phospholipase C antibody; Phosphoinositide phospholipase C-beta-3 antibody; Phospholipase C beta 3 antibody; Phospholipase C beta 3 (phosphatidylinositol specific) antibody; Phospholipase C-beta-3 antibody; PLC beta 3 antibody; PLC-beta-3 antibody; Plcb3 antibody; PLCB3_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from Human PLC β3 around the non-phosphorylation site of S537.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
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基因功能參考文獻：
- Data suggest that 300-residue C-terminal domain of PLCB3 promotes adsorption to phospholipid monolayer/membrane bilayer and is required for spatial organization/adsorption of PLCB3 on membrane surface; defects in phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis alter monolayer adsorption, thus, suggesting role of active site in this process; PLCB3 is preferentially adsorbed to region of bilayer enriched with PIP2. PMID: 28945350
- These results indicate that the mechanism by which Galphaq and PLC-beta3 mutually regulate each other is far more complex than a simple, two-state allosteric model and instead is probably kinetically determined. PMID: 28842497
- We propose that unliganded PLC-beta exists in equilibrium between a closed conformation observed in crystal structures and an open conformation where the PH domain moves away from the EF hands. Therefore, intrinsic movement of the PH domain in PLC-beta modulates Gbetagamma access to its binding site. PMID: 27002154
- the MCP1-induced cortactin phosphorylation is dependent on PLCb3-mediated PKC activation, and siRNA-mediated down-regulation of either of these molecules prevents cortactin interaction with WAVE2 PMID: 26490115
- membranes are integral for the activation of PLC-beta isozymes by diverse modulators. PMID: 25193662
- the M3 muscarinic receptor maximizes the efficiency of PLCbeta3 signaling beyond its canonical role as a guanine nucleotide exchange factor for Galpha. PMID: 24596086
- This study provides an understanding of the structural basis for the PDZ-mediated NHERF1-PLCbeta3 interaction that could prove valuable in selective drug design against CXCR2-related cancers. PMID: 24642259
- PLCbeta3 is enriched in the cytosol. PMID: 23006664
- phospholipase C-beta3 structure reveals the role of the its distal C-terminal domain PMID: 23377541
- Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer uses PLC-beta3 to activate the Ras-ERK pathway and increase intracellular calcium ion concentrations PMID: 21705626
- Data demonstrate that PLCB3, by regulating intracellular calcium transients, plays a relevant role in amplifying the expression and release of IL-8, the major chemokine recruiting neutrophils in CF airway lungs. PMID: 21411730
- Activation of hPLCbeta3 by U73122 required covalent modification of cysteines as evidenced by the observation that enzyme activation was attenuated by thiol-containing nucleophiles, l-cysteine and glutathione. PMID: 21266572
- Studies indicate that the complex between the effector protein phospholipase C-beta3 (PLC-beta3) and its activator, Galpha(q), suggests that several effectors independently evolved a structurally similar helix-turn-helix segment for G protein recognition. PMID: 21304157
- study describe the structure of PLC-beta3 in an activated complex with Galphaq, which together with supporting biochemical and physiological analyses reveals its mechanism of transmembrane signaling PMID: 20966218
- PLC beta 3 and PLC beta 1 bind to calmodulin PMID: 12821674
- findings demonstrated that G-protein-activated phospholipase C-beta interacts with cell polarity proteins Par3 and Par6 to form protein complexes and to mediate downstream signal transduction PMID: 15782111
- reduced Ca(2+) signaling in high glucose cannot be explained by reduced Ca(2+) stores but is due to conventional PKC-dependent phosphorylation and inactivation of PLC-beta(3) PMID: 15998840
- Homodimerization of PLC-beta3 and PLC-beta1 isoenzymes was observed but heterodimerization of these isoenzymes was not detected. PMID: 16763092
- Fission of transport carriers at the trans-Golgi network is dependent on specifically PLCbeta3, which is necessary to activate PKCeta and PKD in that Golgi compartment, via diacylglycerol production. PMID: 17492941
- both negative crosstalk from the cAMP/PRKA pathway and a negative feedback loop in the oxytocin/G protein/PLCB pathway involving PRKC operate in myometrial cells PMID: 18322273
- PLCbeta3 may provide a selective target for inhibiting Ca(2+) responses to mediators of inflammation, including C5a, UDP, PAF, and LPA PMID: 18411281
- VEGF, specifically through VEGFR2, induces phosphorylation of two serine residues on PLCbeta3. PMID: 19295129
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亞細胞定位：Cytoplasm. Membrane. Nucleus.
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