PLAGL2 Antibody, FITC conjugated
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中文名稱：PLAGL2兔多克隆抗體, FITC偶聯(lián)
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貨號：CSB-PA891980LC01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) PLAGL2 Polyclonal antibody
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Uniprot No.：
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基因名：PLAGL2
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別名：C2H2 type zinc finger protein antibody; KIAA0198 antibody; PLAGL2 antibody; PLAL2_HUMAN antibody; Pleiomorphic adenoma gene-like 2 antibody; Pleiomorphic adenoma-like protein 2 antibody; Zinc finger protein PLAGL2 antibody; ZNF900 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Zinc finger protein PLAGL2 protein (324-469AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Shows weak transcriptional activatory activity.
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基因功能參考文獻：
- overexpression of miR-449a inhibited the expression of PLAGL2 significantly and the knockdown of PLAGL2 expression inhibited the breast cancer cell proliferation and metastasis PMID: 29653747
- increased expression correlates to prostate cancer progression following radical prostatectomy and may serve as novel poor prognostic marker PMID: 27537362
- Our findings indicated that PLAGL2 might be a very upstream key molecule regulating Epithelial-mesenchymal transition involved in Wnt/bcatenin signaling pathway in Colorectal adenocarcinoma PMID: 28259923
- Our findings indicate that PALGL2 serves as a tumor oncoprotein in the development and progression of colorectal cancer PMID: 25031728
- PLAGL2 expression induces lamellipodia formation and disruption of stress fiber formation. PMID: 24675530
- PLAGL2 regulate cell cycle and apoptosis via activation of the p53 family member, p73, in human promonocytic U937 cells. PMID: 22076304
- Transcriptome analysis revealed that these differentiation-suppressive activities are attributable in part to PLAGL2 modulation of Wnt/beta-catenin signaling PMID: 20478531
- The data identify PC2 as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation. PMID: 20025940
- PLAGL2 may modulate SP-C expression during lung development. PMID: 15361364
- Coexpression of Tip60 and PLAGL2 completely abolishes the sumoylation of PLAGL2. PMID: 17551969
- Nuclear PLAGL2 occupied and transactivated the endogenous SP-C promoter in hypoxic lung cells.These results further suggest that PLAGL2 is an oxidative stress responding regulator in lung cells. PMID: 17618602
- This study thus uncovers a novel function of PLAGL2 as an oncoprotein through regulating the stability of Pirh2. PMID: 17950244
- These data suggests that Ubc9 can function as a co-factor of PLAGL2, uncoupling from its enzymatic activity, to mediate PLAGL2 interactive SP-C promoter activity. PMID: 18655774
- Increased cell injury and/or death could be caused directly by the upregulation of bNip3, a preapoptotic molecule that dimerizes with Bcl-2, or indirectly by the aberrant expression of SP-C-induced endoplasmic reticulum stress in epithelial cells. PMID: 19574421
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亞細胞定位：Nucleus.
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蛋白家族：Krueppel C2H2-type zinc-finger protein family
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