PKP4 Antibody
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中文名稱：PKP4兔多克隆抗體
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貨號：CSB-PA018083GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：PKP4
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別名：Catenin 4 antibody; Catenin4 antibody; FLJ31261 antibody; FLJ42243 antibody; p0071 antibody; PKP 4 antibody; PKP4 antibody; PKP4_HUMAN antibody; Plakophilin 4 antibody; Plakophilin-4 antibody; Plakophilin4 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human PKP4
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
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基因功能參考文獻：
- p0071 is required for directional vesicle movement and secretion of different KIF3-transported carriers, thereby regulating the transport of intracellular membrane vesicles along microtubules. PMID: 28808088
- Data show that patients with both abnormal expression of p0071 and E-cadherin had a statistically significant shorter survival than the patients without both abnormal expression. PMID: 28898462
- p0071 has a key role in regulating recycling through the Rab11a-dependent perinuclear recycling compartment. PMID: 24163434
- This review article focuses on the functions of the p0071 protein and its closest relatives in regulating cell adhesion and cytoskeletal organization, which are critically involved in the control of cell polarity. [review] PMID: 23640939
- Findings suggest that aspects of folliculin tumour suppressor function are linked to interaction with p0071 and the regulation of RhoA signalling. PMID: 22965878
- These data support a model in which dysregulation of the FLCN-p0071 interaction leads to alterations in cell adhesion, cell polarity, and RhoA signaling. PMID: 23139756
- The structural and functional roles of p0071 are suggested by its preferential occurrence in distinct tubule segments, and its potential use as a cytodiagnostic cell type marker in renal pathology is discussed. PMID: 19830446
- ERBIN interacts in vivo with p0071 and that it may be involved in the organization of adherens junctions and the desmosomes of epithelia PMID: 12047349
- In addition to plakoglobin, p0071 is the second armadillo protein present in both types of adhesive junctions and may play a role in regulating crosstalk between adherens junctions and desmosomes. PMID: 12615965
- p0071 bound to the first 160 amino-terminal residues of desmoplakin and also interacted directly with plakoglobin, suggesting that p0071 may regulate desmosome assembly by controlling plakoglobin availability PMID: 15304078
- These findings support an essential role for p0071 in spatially regulating restricted Rho signalling during cytokinesis. PMID: 17115030
- In this review p0071 catenin, a close relative of p120 catenin, associates and regulates RhoA-GTPase at the cleavage furrow during cytokinesis. PMID: 17264675
- Protein p0071 has been localized as a plaque protein in adhaerens junctions of diverse epithelia and certain vascular endothelia. PMID: 19005682
- Data indicate that p0071 and Ect2 are transported via distinct motors and identify a novel pathway implicating KIF3 in the regulation of actin organization during cytokinesis. PMID: 19339549
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亞細胞定位：Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell membrane; Peripheral membrane protein. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.
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蛋白家族：Beta-catenin family
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數據庫鏈接：
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