PIK3R5 Antibody
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中文名稱：PIK3R5兔多克隆抗體
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貨號：CSB-PA288007
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規(guī)格：￥2024
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圖片：
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Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using PIK3R5 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PIK3R5 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from internal of Human PIK3R5.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:200 IF 1:100-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.
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基因功能參考文獻：
- data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 in PI3Kgamma activation. PMID: 26173259
- PIK3R5 promoter hypermethylation is associated with oral squamous cell carcinoma. PMID: 25374236
- expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways. PMID: 24014027
- Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis. PMID: 22065524
- p101 has a role in membrane recruitment and activation of PI3K gamma PMID: 12507995
- analysis of functional domains in the p101 regulatory subunit of phosphoinositide 3-kinase gamma PMID: 15611065
- Overexpression of p101 activates PI3Kgamma signaling and is associated with T-cell lymphomas PMID: 17486067
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相關疾病：Ataxia-oculomotor apraxia 3 (AOA3)
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亞細胞定位：Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
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組織特異性：Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.
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數(shù)據(jù)庫鏈接：
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