PIK3R4 Antibody
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中文名稱：PIK3R4兔多克隆抗體
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貨號：CSB-PA158009
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA158009(PIK3R4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA158009(PIK3R4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：MGC102700 antibody; P150 antibody; Phosphatidylinositol 3 kinase associated p150 antibody; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 4 antibody; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 4 p150 antibody; Phosphoinositide 3 kinase adaptor protein antibody; Phosphoinositide 3 kinase regulatory subunit 4 antibody; Phosphoinositide 3 kinase regulatory subunit 4 p150 antibody; Phosphoinositide 3 kinase regulatory subunit polypeptide 4 antibody; Phosphoinositide 3 kinase regulatory subunit polypeptide 4 p150 antibody; Phosphoinositide 3-kinase adaptor protein antibody; Phosphoinositide 3-kinase regulatory subunit 4 antibody; PI3 kinase p150 subunit antibody; PI3-kinase p150 subunit antibody; PI3-kinase regulatory subunit 4 antibody; PI3R4_HUMAN antibody; PIK3R 4 antibody; PIK3R4 antibody; VPS 15 antibody; VPS15 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthetic peptide of Human PIK3R4
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2.
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基因功能參考文獻：
- A missense mutation in PIK3R4 (phosphoinositide 3-kinase regulatory subunit 4, named VPS15) in a family with a ciliopathy phenotype is identified. Besides being required for trafficking and autophagy, we show that VPS15 regulates primary cilium length in human fibroblasts. PMID: 27882921
- Both Danon Disease and glycogen storage disease type II show accumulation and altered localization of VPS15 in autophagy-incompetent fibers. However, TFEB displays a different pattern between these two lysosomal storage diseases PMID: 28102838
- High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia. PMID: 25840748
- A specific sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates both receptor degradation and cytokinesis, whereas ATG14L, a PI3K-III subunit involved in autophagy, is not required. PMID: 20643123
- hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells PMID: 18957027
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亞細胞定位：Late endosome. Cytoplasmic vesicle, autophagosome. Membrane; Lipid-anchor.
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蛋白家族：Protein kinase superfamily, Ser/Thr protein kinase family
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組織特異性：Ubiquitously expressed.
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數據庫鏈接：
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