PIK3AP1 Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PIK3AP1 Polyclonal antibody
Uniprot No.：

Q6ZUJ8
基因名：

PIK3AP1
別名：

PIK3AP1 antibody; BCAPPhosphoinositide 3-kinase adapter protein 1 antibody; B-cell adapter for phosphoinositide 3-kinase antibody; B-cell phosphoinositide 3-kinase adapter protein 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Phosphoinositide 3-kinase adapter protein 1 protein (293-404AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
基因功能參考文獻：
1. Dimeric BCAP associates with the TIR domains of TLR2/4 and MAL/TIRAP, suggesting that it is recruited to the TLR signalosome by multitypic TIR-TIR interactions. PMID: 27909057
2. Abi-1 promotes Abl-mediated BCAP phosphorylation and suggest that Abi-1 in general coordinates kinase-substrate interactions PMID: 15893754
亞細胞定位：

Cytoplasm. Cell membrane; Peripheral membrane protein.
組織特異性：

Expressed in natural killer (NK) cells.
數據庫鏈接：

HGNC: 30034

OMIM: 607942

KEGG: hsa:118788

STRING: 9606.ENSP00000339826

UniGene: Hs.310456

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