PHLDA1 Antibody

中文名稱：

PHLDA1兔多克隆抗體
貨號：

CSB-PA845148LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA845148LA01HU at dilution of 1: 100

Immunofluorescence staining of HepG2 cells with CSB-PA845148LA01HU at 1: 133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized tissue using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) .
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PHLDA1 Polyclonal antibody
Uniprot No.：

Q8WV24
基因名：

PHLDA1
別名：

Apoptosis associated nuclear protein antibody; Apoptosis-associated nuclear protein antibody; DT1P1B11 antibody; MGC131738 antibody; PHLA1_HUMAN antibody; PHLDA1 antibody; PHRIP antibody; Pleckstrin homology like domain family A member 1 antibody; Pleckstrin homology-like domain family A member 1 antibody; PQ rich protein antibody; PQ-rich protein antibody; PQR protein antibody; Proline- and glutamine-rich protein antibody; Proline- and histidine-rich protein antibody; T cell death associated gene antibody; T CELL DEATH ASSOCIATED GENE 51 antibody; T-cell death-associated gene 51 protein antibody; Tdag antibody; TDAG51 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Pleckstrin homology-like domain family A member 1 protein (1-138AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PHLDA1 Antibody (CSB-PA845148LA01HU)，的標記方式是Non-conjugated。對于PHLDA1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA845148LB01HU	PHLDA1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA845148LC01HU	PHLDA1 Antibody, FITC conjugated
Biotin	CSB-PA845148LD01HU	PHLDA1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.
基因功能參考文獻：
1. suggest a unique regulatory feature of PHLDA1 to inhibit the ErbB receptor oligomerization process and thereby control the activity of receptor signaling network. PMID: 29233889
2. Data identified PHLDA1 as a novel p53 target with an ability to repress Akt. PHLDA1 has a so-called split PH domain divided into an N-terminal and a C-terminal portions and seems to be responsible for its localization to the plasma membrane and binding to phosphatidylinositol. In addition, PHLDA1 expression analysis suggests that PHLDA1 has a tumor suppressive function in breast and ovarian cancers. PMID: 30207029
3. Our study negatively correlates expression of PHLDA1 and Aurora A in IMR-32 cells and sheds new light on functions of PHLDA1 in the neuroblastoma tumor cells, suggesting its role as a pro-apoptotic protein PMID: 27278006
4. Suggest decreased expression of PHLDA1 may play an important role in tumor progression, and may become a new adjunct biomarker in the prognosis in gastric adenocarcinoma. PMID: 26191222
5. Data suggest that high PHLDA1 expression is controlled through an ER-NFkappaB-miR-181 regulatory axis and may contribute to a poor clinical outcome in patients with ER+ breast tumors by enhancing stem-like properties in these tumors. PMID: 24954507
6. PHLDA1 expression is a useful addition in differentiating trichoblastoma and basal cell carcinoma. PMID: 23719479
7. A role for PHLDA1 as an apoptosis suppressor in oral cancer cells. PMID: 24270013
8. Data show that downregulation of aurora A kinase by the therapeutic antibody is associated with decreased levels of MYCN protein in cytoplasm, and induced expression of PHLDA1 and P53 proteins. PMID: 23962557
9. The follicular stem cell marker PHLDA1 (TDAG51) indicates that most basaloid tumors in nevus sebaceus are basal cell carcinomas and not trichoblastomas. PMID: 23489134
10. PHLDA1 differentiates between desmoplastic trichoepithelioma and morpheaform basal cell carcinoma but shows variable staining in microcystic adnexal carcinoma. PMID: 23398472
11. the release of Ca(2+) from endoplasmic reticulum stores mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium via the induction of TDAG51 PMID: 22592641
12. crucial negative regulator and effector of Aurora A kinase in breast cancer PMID: 21807936
13. PHLDA1 expression marks the putative epithelial stem cells, downregulates ITGA2 and ITGA6, and contributes to intestinal tumorigenesis PMID: 21558389
14. The progressive loss of PHLDA1 expression in melanomas may play a role in deregulated cell growth and apoptosis resistance in these tumors. PMID: 12384558
15. expression of TDAG51 in human T-cells does not correlate with activation-induced cell death PMID: 15002043
16. TDAG51 plays an important role in the anti-apoptotic effects of IGF-I. PMID: 15037619
17. TDAG51 locus shows an operon-like organization of two head-to-head oriented transcripts that are inversely regulated in T lymphocytes by a CpG-rich bidirectional promoter. PMID: 15315823
18. Reduced PHLDA1 expression is important in breast cancer progression and could serve as useful prognostic marker of disease outcome. PMID: 17211533
19. TDAG51 in patients with intractable epilepsy was significantly higher when compared with levels in the controls. PMID: 17870236
20. The anti-estrogen ICI 182,780 (1 microM) inhibited PHLDA1 mRNA expression and completely abolished the effect of 10 nM 17beta-estradiol on PHLDA1 expression (P < 0.05), suggesting that PHLDA1 is regulated by estrogen via ER. PMID: 18641796
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亞細胞定位：

Cytoplasm. Cytoplasmic vesicle. Nucleus, nucleolus.
組織特異性：

Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).
數據庫鏈接：

HGNC: 8933

OMIM: 605335

KEGG: hsa:22822

STRING: 9606.ENSP00000266671

UniGene: Hs.602085

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