PHC1 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PHC1 Polyclonal antibody
Uniprot No.：

P78364
基因名：

PHC1
別名：

Early development regulatory protein 1 antibody; hPH1 antibody; mPH1 antibody; PH1 antibody; Phc1 antibody; PHC1_HUMAN antibody; Polyhomeotic-like protein 1 antibody; Rae28 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Polyhomeotic-like protein 1 protein (142-225AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
基因功能參考文獻：
1. These findings reveal several cellular defects in cells carrying the PHC1 mutation and highlight the role of chromatin remodeling in the pathogenesis of PM. PMID: 23418308
2. PcG complex 1, involving Rae28 and Cdt1, supports the activity of hematopoietic stem cells by enhancing cycling capability and hematopoietic activity through direct regulation of Geminin PMID: 18650381
相關疾病：

Microcephaly 11, primary, autosomal recessive (MCPH11)
亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 3182

OMIM: 602978

KEGG: hsa:1911

STRING: 9606.ENSP00000251757

UniGene: Hs.744902

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