PFN1 Antibody
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中文名稱：PFN1兔多克隆抗體
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貨號：CSB-PA017824GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Actin binding protein antibody; ALS18 antibody; Epididymis tissue protein Li 184a antibody; OTTHUMP00000125244 antibody; PFN 1 antibody; Pfn antibody; PFN1 antibody; PROF1_HUMAN antibody; Profilin I antibody; Profilin-1 antibody; Profilin1 antibody; ProfilinI antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human PFN1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
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基因功能參考文獻：
- Variants of rs238243 and rs238238 might regulate profilin1 expression by epigenetic modification and indirectly affects the susceptible threshold of hypertension in Chinese Han population. PMID: 28541412
- Results suggested that the RhoA/ROCK1 pathway activated by excessive ROS is responsible for profilin-1-mediated endothelial damage. PMID: 29849894
- PFN1 could promote autophagy through taking part in Beclin1 complex and contribute to bortezomib resistance, which may become a novel molecular target in the therapy of MM. PMID: 29945297
- Loss of PFN1 in tumor cells has been associated with lymph node invasion and metastasis in other tumor types, strengthening the argument that the protein has the potential to be a tumor suppressor in late-stage oral squamous cell carcinoma. PMID: 27862305
- Guttiferone K effectively suppresses the motility and metastasis of hepatocellular carcinoma cells mainly by restoration of aberrantly reduced PFN1 protein expression PMID: 27494863
- Results collectively suggest that PFN1 promotes cell migration and adhesion in bladder cancer models. PMID: 27683119
- These results suggest that although mutant PFN1 aggregation may contribute to neurodegeneration, it does not trigger its onset. Importantly, these experiments establish a progressive disease model that can contribute toward identifying the mechanisms of ALS pathogenesis and the development of therapeutic treatments. PMID: 27681617
- One potential mechanism for C71G-PFN1 to initiate Amyotrophic lateral sclerosis might be the abnormal interaction with membranes as recently established for SOD1 mutants. PMID: 28847504
- Expression of PFN1 mutants induces accumulation of TDP-43, and promotes conversion of normal TDP-43 into an abnormal form. These results provide new insight into the mechanisms of TDP-43 proteinopathies and other diseases associated with amyloid-like protein deposition. PMID: 27432186
- We suggest that reduction of PFN-1 expression by elevated levels of PrP(c) may contribute to protective effects PrP(c)-overexpressing SH-SY5Y cells confer against STS-induced apoptosis PMID: 28102851
- this study shows that in pancreatic cancer patients, PFN1 expression is substantially decreased in peripheral CD8(+) T cells PMID: 28688208
- mutant profilin1 in various diseases with an emphasis on its contribution to the pathogenesis of amyotrophic lateral sclerosis (Review) PMID: 27669692
- Data suggest 2 major isoforms of profilin (Pfn1 and Pfn2) are co-regulated by a common mechanism involving the action of MKL1 [megakaryoblastic leukemia (translocation) 1 protein] that is independent of its SRF- (serum-response factor)-related activity; cellular externalization of Pfn1, rather than transcription, is affected by the perturbations of MKL1; MKL1 can influence cell migration by modulating Pfn1 expression. PMID: 28546428
- novel profilin-1 variants associated with amyotrophic lateral sclerosis PMID: 27101547
- We found that ARP3 and profilin1 were 2 binding partners of LMO2, primarily in cytoplasm. LMO2. LMO2 mediated the assembly of a complex including ARP3, profilin1, and actin monomer, increased actin monomer binding to profilin1, and promoted lamellipodia/filopodia formation in basal-type breast cancer cells. PMID: 28170369
- These observations indicate that our novel profilin1 mutant mouse line may provide a new ALS model with the opportunity to gain unique perspectives into mechanisms of neurodegeneration that contribute to ALS pathogenesis. PMID: 28040732
- These data suggest that Familial Amyotrophic Lateral Sclerosis-linked PFN1 mutations exacerbate TDP-43-induced neurodegeneration in a gain-of-function manner, possibly by shifting the localization of TDP-43 from nuclei to cytoplasm. PMID: 27634045
- Homo-oligomerization of the actin-binding protein PFN1 has been characterized by the relaxation dispersion profiles of the protein as a function of concentration. PMID: 28052669
- Gain-of-toxic-function PFN1 gene mutation leads to conformational change of TDP-43 and to neurodegeneration in amyotrophic lateral sclerosis. PMID: 26908597
- Profilin synergizes with chemotherapeutic drugs to induce tumor cell death by regulating NF-kappaB and p53. Thus, modulation of Profilin may be a useful strategy for effective combination therapy. PMID: 26842845
- Mutations of profilin-1, associated with familial amyotrophic lateral sclerosis, increase the tendency of profilin-1 to aggregate and that such aggregation behavior is largely determined by the mutation-induced structural changes occurring in the folded state of the protein. PMID: 26226631
- evidence, which suggests that Profilin increases tumour suppressor activity by regulating NF-kappaB. PMID: 26787927
- Profilin-1 folding process occurs in the absence of thermodynamically stable partially folded states. PMID: 26227615
- Actin independent mechanisms contribute to the pathogenicity of PFN1 T109M and possibly other PFN1 mutations. PMID: 26572741
- expression of the ALS-associated actin-binding deficient mutant of PFN1 (PFN1(C71G)) results in increased dendritic arborisation and spine formation, and cytoplasmic inclusions in cultured mouse hippocampal neurons PMID: 26499959
- PFN1 is a rare cause of ALS. PMID: 25499087
- findings suggest that a destabilized form of PFN1 underlies PFN1-mediated ALS pathogenesis PMID: 26056300
- Suggest that PFN1 plays a critical role in gastric carcinoma progression, and these effects are likely mediated through the integrin beta1/FAK pathway. PMID: 25741138
- Data indicated that No PFN1 mutations were identified in the Catalan population with amyotrophic lateral sclerosis. PMID: 25249294
- Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses PMID: 25454514
- Profilin1 acts as a molecular regulator of the levels of PI(3,4)P2 and Tks5 recruitment in invadopodia to control the invasion efficiency of invadopodia. PMID: 25613364
- Collective expression pattern of tensin/profilin-1/villin-1/talin could be a biomarker to estimate the prognosis of esophageal squamous cell carcinoma patients. PMID: 25337239
- Pfn1 is a tumor suppressor in pancreatic cancer that acts via a novel mechanism of regulating the SIRT3-HIF1alpha axis. PMID: 25103363
- Higher messenger RNA expression of Profilin-1 is associated with significantly lower survival PMID: 25704627
- the exchange of bound actin between Tbeta4 and profilin involves both steric and allosteric components. PMID: 25313062
- effects of profilin-1 and profilin-2, the two major isoforms of profilin, on actin cytoskeletal regulation, motility, and invasion of breast cancer cells PMID: 23827010
- This review summarize the PFN1 most recently discovered 'high risk' genes in ALS. PMID: 24780888
- association of cortactin with Pfn-1 is regulated by c-Abl-mediated cortactin phosphorylation PMID: 24700464
- Raising the intracellular levels of Profilin I decreased the mobile fraction ratio of actin filaments and slowed their polymerization rate. PMID: 24465723
- In glioblastomas endothelial cell-specific Pfn-1 phosphorylation elevates HIF-1alpha expression leading to vascular abnormalities and tumor progression. PMID: 24747440
- The ALS-linked mutations in profilin 1 alter stress granule dynamics, providing further evidence for the potential role of stress granules in ALS pathogenesis. PMID: 24920614
- CHIP regulates Pfn1 levels as an E3 ligase, and possibly plays a role in cell migration and metastasis of breast cancer. PMID: 24661873
- Data indicate that lower profilin1 (Pfn1) expression is associated with increased metastatic potential in breast cancer. PMID: 23686314
- PFN1 mutations were identified in autosomal dominant FALS patients. PMID: 24085347
- Profilin-1 might act as an ultimate and common cellular effector in the process of metabolic memory (endothelial abnormalities) mediated by AGEs via the ROS/PKC or ROS/NF-B signalling pathways. PMID: 24090212
- Wanted to identify estrogen receptor alpha (ERalpha) interacting proteins in Tamoxifen treated MCF7 cells. Using a GST-pull down assay with ERalpha ligand-binding domain and MS-based proteomics approach we identified Profilin1 as a novel ERalpha interacting protein. PMID: 23576398
- up-regulation of profilin1 facilitated apoptosis and repressed autophagy induced by irradiation. PMID: 23826918
- PFN1 mutations lead to ubiquitin-positive inclusions and impairment of cytoskeletal pathways, in which, a pathophysioloy of familial and sporadic ALS lays. PMID: 23635659
- The single nucleotide polymorphism (SNP) rs13204 of the PFN1 gene has an important function in the development of amyotrophic lateral sclerosis in Han Chinese. PMID: 23428184
- PFN1 mutations are not a common cause of frontotemporal lobar degeneration and amyotrophic lateral sclerosis in this cohort of patients from France. PMID: 23182804
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相關疾病：Amyotrophic lateral sclerosis 18 (ALS18)
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亞細胞定位：Cytoplasm, cytoskeleton.
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蛋白家族：Profilin family
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組織特異性：Expressed in epididymis (at protein level).
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