PES1 Antibody

中文名稱：

PES1兔多克隆抗體
貨號：

CSB-PA017791LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Mouse heart tissue
All lanes: PES1 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69, 68 kDa
Observed band size: 69 kDa

Immunofluorescent analysis of PC-3 cells using CSB-PA017791LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PES1 Polyclonal antibody
Uniprot No.：

O00541
基因名：

PES1
別名：

FLJ43790 antibody; Homo sapiens pescadillo mRNA complete cds antibody; PES antibody; PES 1 antibody; pes1 antibody; PESC_HUMAN antibody; Pescadillo (zebrafish) homolog 1 containing BRCT domain antibody; Pescadillo homolog 1 antibody; Pescadillo homolog 1 containing BRCT domain (zebrafish) antibody; Pescadillo homolog antibody; Pescadillo ribosomal biogenesis factor 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human Pescadillo homolog protein (378-588AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，PES1 Antibody (CSB-PA017791LA01HU)，的標記方式是Non-conjugated。對于PES1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA017791LB01HU	PES1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017791LC01HU	PES1 Antibody, FITC conjugated
Biotin	CSB-PA017791LD01HU	PES1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
基因功能參考文獻：
1. posttranslational modification of PES1 by SUMOylation may serve as a key factor that regulates the function of PES1 in vivo PMID: 27409667
2. PES1 may play an important role in development of gastric cancer. PMID: 26423399
3. PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERalpha and ERbeta expression. PMID: 24376209
4. these results uncover a potential role of PES1 in chemoresistance by regulating DNA damage response in colorectal cancer cells. PMID: 23333390
5. Upstream of c-Jun, it was revealed that c-Jun NH2-terminal kinases (JNK) is essential for controlling PES1 expression PMID: 22860098
6. expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer PMID: 22820289
7. The physical interaction between B23 and PES1 implies that they may participate in ribosome biogenesis in a protein complex. PMID: 20011973
8. pescadillo might play a role in promoting the proliferation and carcinogenesis of human breast cancer, and thereby might be a potential target for human breast cancer treatment. PMID: 19764998
9. Mechanisms for the ability of Pes1 to transform cells, and its failure to immortalize them. PMID: 15273728
10. RRB1 interacts with YPH1 (yeast pescadillo homologue 1) and other members of the Yph1 complex PMID: 15467761
11. Pes1 and Bop1 form a stable complex with a novel member, WDR12 (PeBoW complex). PMID: 16043514
12. Results describe the role of PeBoW-specific proteins Pes1, Bop1, and WDR12 in complex assembly and stability, nucleolar transport, and pre-ribosome association. PMID: 17353269
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亞細胞定位：

Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome.
蛋白家族：

Pescadillo family
組織特異性：

Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.
數(shù)據(jù)庫鏈接：

HGNC: 8848

OMIM: 605819

KEGG: hsa:23481

STRING: 9606.ENSP00000346725

UniGene: Hs.517543

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