PEBP4 Antibody, FITC conjugated

說明書

中文名稱：

PEBP4兔多克隆抗體, FITC偶聯
貨號：

CSB-PA857025LC01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PEBP4 Polyclonal antibody
Uniprot No.：

Q96S96
基因名：

PEBP4
別名：

PEBP4 antibody; CORK1 antibody; UNQ1933/PRO4408 antibody; Phosphatidylethanolamine-binding protein 4 antibody; PEBP-4 antibody; hPEBP4 antibody; Protein cousin-of-RKIP 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Phosphatidylethanolamine-binding protein 4 protein (23-227AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway.
基因功能參考文獻：
1. PEBP4 was associated with the development and invasion of gastric cancer cells through activation of the PI3K/Akt signaling pathway PMID: 28193908
2. knockdown of PEBP4 inhibited hypoxia-induced epithelial-to-mesenchymal transition in prostate cancer cells. PMID: 27261570
3. this study suggested that PEBP4 might promote the progression of pancreatic ductal adenocarcinoma PMID: 26311050
4. Increased expression of phosphatidylethanolamine-binding protein 4 strongly associates with gliomas grade. PMID: 26725095
5. PEBP4 is a secreted protein and has multiple functions, including a role in Akt phosphorylation. PMID: 27033522
6. Increased miR-15b expression in lung adenocarcinoma patients treated with cisplatin-based chemotherapy was correlated with low expression of PEBP4, decreased sensitivity to cisplatin and poor prognosis. PMID: 25721211
7. concluded that hPEBP4, specifically expressed in rectal cancer cells, is associated with radioresistance of rectal cancer PMID: 24594691
8. overexpression of PEBP4, which we show to be a target of miR-34a, reduces the sensitivity of lung cancer cells to cisplatin PMID: 25038915
9. in human breast cancer hPEBP4 is a novel and clinically relevant metastasis accelerator gene PMID: 24276246
10. Human PEBP4 expression correlates negatively with estrogen and progesterone receptors in endometrial carcinoma. PMID: 23818363
11. hPEBP4 knockdown potentiated the chemosensitization of the rituximab in B-cell lymphoma cells by regulating the expression of Bcl-xl, Cycline E, p21(waf/cip1) and p53 and the activation of caspase-3 and caspase-9. PMID: 23451095
12. the independent predictive values of hPEBP4 in response of rectal cancer to preoperative radiotherapy, are reported. PMID: 22801881
13. PEBP4 enhanced cell proliferation and invasion ability and inhibited apoptosis. Decreased PEBP4 expression may play a role in the reduced invasion ability and increased apoptosis of the human non-small cell lung cancer cell line HCC827. PMID: 22983920
14. PEBP4 over-expression may promote the invasion and metastasis of non-small cell lung cancer. PMID: 22076923
15. The over-expression of PEBP4 protein may be related to the tumorigenesis, development, metastasis, and invasion of colorectal cancer. PMID: 22125029
16. Data show that PEBP4 protein overexpression was associated with the occurrence, invasion, and metastasis of lung squamous cell carcinoma. PMID: 21887552
17. hPEBP4 inhibits proteasome-dependent ERalpha degradation through the Src pathway. PMID: 20460377
18. hPEBP4 promotes cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK, and PE externalization. PMID: 15302887
19. Silencing of hPEBP4, an important potential target, may be a promising approach for the treatment of ovarian cancer. PMID: 16865237
20. Data show that PEBP4 participates in the control of muscle cell differentiation by modulating the activity of MEK and ERK. PMID: 19197339
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亞細胞定位：

Secreted.
蛋白家族：

Phosphatidylethanolamine-binding protein family
數據庫鏈接：

HGNC: 28319

OMIM: 612473

KEGG: hsa:157310

STRING: 9606.ENSP00000256404

UniGene: Hs.491242

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