PEAK1 Antibody

中文名稱：

PEAK1兔多克隆抗體
貨號：

CSB-PA875688LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA875688LA01HU diluted at 1:200 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PEAK1 Polyclonal antibody
Uniprot No.：

Q9H792
基因名：

PEAK1
別名：

FLJ21140 antibody; FLJ34483 antibody; KIAA2002 antibody; NKF3 kinase family member antibody; PEAK1 antibody; PEAK1_HUMAN antibody; pseudopodium enriched atypical kinase antibody; Pseudopodium-enriched atypical kinase 1 antibody; SGK269 antibody; Sugen kinase 269 antibody; Tyrosine-protein kinase SgK269 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Pseudopodium-enriched atypical kinase 1 protein (715-881AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PEAK1 Antibody (CSB-PA875688LA01HU)，的標記方式是Non-conjugated。對于PEAK1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA875688LB01HU	PEAK1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA875688LC01HU	PEAK1 Antibody, FITC conjugated
Biotin	CSB-PA875688LD01HU	PEAK1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.
基因功能參考文獻：
1. PEAK1's kinase cleft is occluded, and its newly identified SHED region may promote an unexpected dimerization mode. Similarities of PEAK1 with the active kinase PINK1 may reclassify the latter as a member of the new kinase family 3 group. PMID: 29212708
2. the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9. PMID: 27531744
3. Findings indicate that eIF5A-PEAK1-YAP signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity. PMID: 28381547
4. report is the first to provide evidence that PEAK1 mediates signaling cross talk between TGFbeta receptors and integrin/Src/MAPK pathways and that PEAK1 is an important molecular regulator of TGFbeta-induced tumor progression and metastasis in breast cancer PMID: 26267863
5. this regard, we have demonstrated that PEAK1 is necessary for TGFbeta to induce ZEB1-mediated EMT in the context of fibronectin/ITGB3 activation. PMID: 26297948
6. Suggest that loss of PEAK1/E-cadherin may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition. PMID: 25445115
7. eIF5A proteins utilize PEAK1 as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis. PMID: 25261239
8. results define a novel signaling pathway in basal breast cancer involving Lyn and SgK269 that offers clinical opportunities for therapeutic intervention PMID: 23378338
9. phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover PMID: 23105102
10. Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN). PMID: 22589274
11. Also known as SgK269. Contains a divergent and possibly inactive eukaryotic protein kinase domain. Has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms PMID: 12471243
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亞細胞定位：

Cytoplasm, cytoskeleton. Cell junction, focal adhesion.
蛋白家族：

Protein kinase superfamily
數據庫鏈接：

HGNC: 29431

OMIM: 614248

KEGG: hsa:79834

STRING: 9606.ENSP00000309230

UniGene: Hs.731402

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