PCSK7 Antibody

中文名稱：

PCSK7兔多克隆抗體
貨號：

CSB-PA017646LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA017646LA01HU diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PCSK7 Polyclonal antibody
Uniprot No.：

Q16549
基因名：

PCSK7
別名：

hPC8 antibody; LPC antibody; Lymphoma proprotein convertase antibody; PC7 antibody; PC8 antibody; Pcsk7 antibody; PCSK7_HUMAN antibody; Prohormone convertase 7 antibody; Prohormone convertase 8 antibody; Proprotein convertase 7 antibody; Proprotein convertase 8 antibody; Proprotein convertase PC7 antibody; Proprotein convertase subtilisin/kexin type 7 antibody; SPC7 antibody; Subtilisin/kexin-like protease PC7 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Proprotein convertase subtilisin/kexin type 7 protein (189-362AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PCSK7 Antibody (CSB-PA017646LA01HU)，的標記方式是Non-conjugated。對于PCSK7 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA017646LB01HU	PCSK7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017646LC01HU	PCSK7 Antibody, FITC conjugated
Biotin	CSB-PA017646LD01HU	PCSK7 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.
基因功能參考文獻：
1. Our present data suggest that PCSK7 as well as PCSK9 may be associated with lipids, especially triglyceride, and may serve as a candidate for a new drug target to treat lipid abnormality syndromes. PMID: 26763881
2. PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-Hemochromatosis. PMID: 26868056
3. Furin and PC7 siRNAs induced HIF-1alpha protein by increasing its translation, resulting in upregulation of VEGF-A. PMID: 24436242
4. The data suggest that PCSK7 genotypes may interact with dietary CHO intake on changes in insulin sensitivity in the white Americans. PMID: 25504030
5. Results demonstrate that PCSK7 variation is a strong host risk factor of liver cirrhosis in hereditary hemochromatosis patients homozygous for HFE C282Y. PMID: 24556216
6. overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner PMID: 23686857
7. Among the PC family members, only furin activates hepcidin in hepatocytes, and uniquely the full-length membrane-bound PC7 can directly shed hTfR1 by cleavage at Arg100 PMID: 23390091
8. Region encoded by amino acids ala713-asp730 is essential and sufficient for endocytosis. PMID: 22294700
9. PCSK7 is involved in sTfR generation and iron homeostasis. PMID: 21149283
10. Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor. PMID: 21209099
11. PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking. PMID: 21075846
12. Mass spectrometry analysis provides evidence that the HLA-B51-presented peptide profile is altered in the absence of peptide-loading complex quality control or lack of PC7 function in major histocompatibility (MHC) class I-mediated antigen presentation. PMID: 20164418
13. we investigated the specificity and potency of complete prodomains and short C-terminal prodomain peptides of each SPC on highly purified, soluble enzyme preparations of human SPC1, SPC6, and SPC7. PMID: 11723118
14. in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only PMID: 17242158
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亞細胞定位：

Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
蛋白家族：

Peptidase S8 family
組織特異性：

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte.
數據庫鏈接：

HGNC: 8748

OMIM: 604872

KEGG: hsa:9159

STRING: 9606.ENSP00000325917

UniGene: Hs.648612

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