PCSK5 Antibody, HRP conjugated

說明書

中文名稱：

PCSK5兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA017644LB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PCSK5 Polyclonal antibody
Uniprot No.：

Q92824
基因名：

PCSK5
別名：

FLJ11149 antibody; FLJ16215 antibody; hPC6 antibody; PC5 antibody; PC6 antibody; PC6A antibody; Pcsk5 antibody; PCSK5_HUMAN antibody; Prohormone convertase 5 antibody; Proprotein convertase 5 antibody; Proprotein convertase 6 antibody; Proprotein convertase PC5 antibody; Proprotein convertase subtilisin/kexin type 5 antibody; Protease PC6 antibody; SPC6 antibody; Subtilisin/kexin-like protease PC5 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Proprotein convertase subtilisin/kexin type 5 protein (201-500AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.
基因功能參考文獻：
1. loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation. PMID: 28468828
2. Case Report: whole exome sequencing of a case with the VACTERL association uncovered a novel frameshift mutation in the PCSK5 gene. PMID: 26055999
3. full-length alpha-DG in the human endometrial epithelium is a barrier for embryo attachment and that removal of alpha-DG-N by proprotein convertase 5/6 (PC6; a protease critical for implantation PMID: 26077903
4. Proprotein convertase 5/6 cleaves PDGFA in the human endometrium in preparation for embryo implantation. PMID: 25429785
5. PC5/6A is involved in squamous differentiation of human nasal epithelial cells, possibly through up-regulation of the BMP-2 signaling pathway. PMID: 25350918
6. study implicates PC6 as a key regulatory protein essential for the attachment of the blastocyst to the endometrial epithelium through the processing of pro-integrin-alphas PMID: 22740495
7. PC6 plays a key role in regulating fundamental cellular remodeling processes, such as plasma membrane transformation and membrane-cytoskeletal interface reorganization. PMID: 21971156
8. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A. PMID: 21700711
9. PC6 may have a role in uterine receptivity and its uterine lavage levels appear to be significantly lower in a subgroup of women with unexplained infertility PMID: 21273245
10. PTPkappa was scissored by the processed form of proprotein convertase 5, and galectin-3 binding protein which is over-produced in colon cancer cells and tissues. PMID: 21094132
11. The proteolytic activation and thus bioavailability of BMP2 is controlled by PC6. PMID: 20555025
12. Variability at the PCSK5 locus influences high-density lipoprotein cholesterol levels. PMID: 20031622
13. Results describe the mechanisms of PC6 action in decidualization and identify caldesmon as one of its physiological substrates. PMID: 19764806
14. PC5/6 plays a key role for decidualization in human endometrium. PMID: 15522936
15. PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation PMID: 15601911
16. in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only PMID: 17242158
17. after stimulation, the protease activity of PC5A is enhanced, as evidenced by the cleavage of the PC5A substrates Lefty, ADAMTS-4, endothelial lipase, and PCSK9. PMID: 18039650
18. We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development. PMID: 18519639
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亞細胞定位：

[Isoform PC6A]: Secreted.; [Isoform PC6B]: Endomembrane system; Single-pass type I membrane protein.
蛋白家族：

Peptidase S8 family
組織特異性：

Expressed in T-lymphocytes.
數(shù)據(jù)庫鏈接：

HGNC: 8747

OMIM: 600488

KEGG: hsa:5125

STRING: 9606.ENSP00000446280

UniGene: Hs.368542

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