PCOLCE Antibody, HRP conjugated
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中文名稱：PCOLCE兔多克隆抗體, HRP偶聯
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貨號：CSB-PA614881LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PCOLCE Polyclonal antibody
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Uniprot No.：
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基因名：PCOLCE
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別名：PCOC1_HUMAN antibody; Pcolce antibody; PCOLE 1 antibody; PCOLE1 antibody; PCPE antibody; PCPE-1 antibody; PCPE1 antibody; Procollagen C endopeptidase enhancer antibody; Procollagen C-endopeptidase enhancer 1 antibody; Procollagen C-endopeptidase enhancer antibody; Procollagen C-proteinase enhancer 1 antibody; Procollagen COOH-terminal proteinase enhancer 1 antibody; procollagen, type 1, COOH-terminal proteinase enhancer antibody; Type 1 procollagen C-proteinase enhancer protein antibody; Type I procollagen COOH-terminal proteinase enhancer antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Procollagen C-endopeptidase enhancer 1 protein (169-449AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.; C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
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基因功能參考文獻：
- Serum PCPE-1 might be used as a noninvasive marker of liver fibrosis in chronic hepatitis B. PMID: 29683980
- Results suggest that PCPE-1 binding to syndecans and/or fibronectin may control collagen fibril assembly on the cell surface. PMID: 25286301
- The analysis of the PCPE-1 interaction network based on Gene Ontology terms suggests that, besides its role in collagen deposition, PCPE-1 might be involved in tumour growth, neurodegenerative diseases and angiogenesis. PMID: 24117177
- The results of this study suggested that nuclear entrapment of PCOLCE and its extracellular depletion represents a novel molecular mechanism in late-onset muscle fibrosis. PMID: 23815790
- Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation. PMID: 23550162
- data generated by our system, support our hypothesis that combined data on PCPE concentration and isoforms may be useful for the diagnosis and follow-up of bone diseases PMID: 21569766
- Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only. PMID: 21940633
- procollagen C-proteinase enhancer-1 (PCPE-1) binds to heparin/heparan sulfate and has a role in interaction with cells PMID: 20729553
- Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity. PMID: 20207734
- Data show that only those containing both PCPE1 CUB1 and CUB2 were capable of enhancing BMP-1 activity and binding to a mini-procollagen substrate with nanomolar affinity. PMID: 19801683
- PCPE binds to sites on either side of the procollagen cleavage site, thereby facilitating the action of procollagen C-proteinases. PMID: 12105202
- PCPE1 and PCPE2 were found to be collagen-binding proteins, capable of binding at multiple sites on the triple helical portions of fibrillar collagens and also capable of competing for such binding with procollagen C-proteinases PMID: 12393877
- procollagen C-proteinase enhancer is an elongated multidomain glycoprotein as shown by small angle x-ray scattering PMID: 12486138
- the three-dimensional structure of the NTR domain of human PCOLCE1 is the first example of a structural domain with the canonical features of an NTR module PMID: 12670942
- chordinase activity of BMP1 is not enhanced by PCPE-1 PMID: 15817489
- tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains PMID: 16507574
- PCPE-stimulating activity requires a calcium binding motif in the CUB1 domain that is highly conserved among CUB-containing proteins PMID: 17446170
- in bone fracture patients, 12 proteins were related to bone/cartilage metabolism, including: TGF-beta induced protein IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein and TGF-beta receptor III. PMID: 17602227
- PCPE-1 interacts with beta2-microglobulin (beta2-m) and may help initiate beta2-m amyloid fibril formation in connective tissues PMID: 18164932
- Procollagen I mRNA expression was decreased by synovial fluid from patients with prosthesis loosening. PMID: 18350290
- the sPCPE1 glycopattern appears to be associated with the physiological and pathological states of bone PMID: 19361460
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亞細胞定位：Secreted.
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